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Migrasome: a new functional extracellular vesicle
Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis depends on the migration process. It is generated in a variety of cells such as immune cells, metastatic tumor cells, other special functional cells like podocytes and cells in developing organisms. It plays i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584828/ https://www.ncbi.nlm.nih.gov/pubmed/37852963 http://dx.doi.org/10.1038/s41420-023-01673-x |
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author | Zhang, Xide Yao, Liuhuan Meng, Yuanyuan Li, Bailong Yang, Yanyong Gao, Fu |
author_facet | Zhang, Xide Yao, Liuhuan Meng, Yuanyuan Li, Bailong Yang, Yanyong Gao, Fu |
author_sort | Zhang, Xide |
collection | PubMed |
description | Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis depends on the migration process. It is generated in a variety of cells such as immune cells, metastatic tumor cells, other special functional cells like podocytes and cells in developing organisms. It plays important roles in various fields especially in the information exchange between cells. The discovery of migrasome, as an important supplement to the extracellular vesicle system, provides new mechanisms and targets for comprehending various biological or pathological processes. In this article, we will review the discovery, structure, distribution, detection, biogenesis, and removal of migrasomes and mainly focus on summarizing its biological functions in cell-to-cell communication, homeostatic maintenance, embryonic development and multiple diseases. This review also creates prospects for the possible research directions and clinical applications of migrasomes in the future. |
format | Online Article Text |
id | pubmed-10584828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105848282023-10-20 Migrasome: a new functional extracellular vesicle Zhang, Xide Yao, Liuhuan Meng, Yuanyuan Li, Bailong Yang, Yanyong Gao, Fu Cell Death Discov Review Article Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis depends on the migration process. It is generated in a variety of cells such as immune cells, metastatic tumor cells, other special functional cells like podocytes and cells in developing organisms. It plays important roles in various fields especially in the information exchange between cells. The discovery of migrasome, as an important supplement to the extracellular vesicle system, provides new mechanisms and targets for comprehending various biological or pathological processes. In this article, we will review the discovery, structure, distribution, detection, biogenesis, and removal of migrasomes and mainly focus on summarizing its biological functions in cell-to-cell communication, homeostatic maintenance, embryonic development and multiple diseases. This review also creates prospects for the possible research directions and clinical applications of migrasomes in the future. Nature Publishing Group UK 2023-10-18 /pmc/articles/PMC10584828/ /pubmed/37852963 http://dx.doi.org/10.1038/s41420-023-01673-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Zhang, Xide Yao, Liuhuan Meng, Yuanyuan Li, Bailong Yang, Yanyong Gao, Fu Migrasome: a new functional extracellular vesicle |
title | Migrasome: a new functional extracellular vesicle |
title_full | Migrasome: a new functional extracellular vesicle |
title_fullStr | Migrasome: a new functional extracellular vesicle |
title_full_unstemmed | Migrasome: a new functional extracellular vesicle |
title_short | Migrasome: a new functional extracellular vesicle |
title_sort | migrasome: a new functional extracellular vesicle |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584828/ https://www.ncbi.nlm.nih.gov/pubmed/37852963 http://dx.doi.org/10.1038/s41420-023-01673-x |
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