Dopaminergic denervation and associated MRI microstructural changes in the nigrostriatal projection in early Parkinson’s disease patients

Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and a profound reduction of striatal dopamine are two hallmarks of Parkinson’s disease (PD). However, it’s unclear whether degeneration starts at the neuronal soma or the striatal presynaptic terminals, and how microstructural...

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Detalles Bibliográficos
Autores principales: López-Aguirre, M., Matarazzo, M., Blesa, J., Monje, M. H. G., Rodríguez-Rojas, R., Sánchez-Ferro, A., Obeso, J. A., Pineda-Pardo, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584921/
https://www.ncbi.nlm.nih.gov/pubmed/37852988
http://dx.doi.org/10.1038/s41531-023-00586-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584921/
https://www.ncbi.nlm.nih.gov/pubmed/37852988
http://dx.doi.org/10.1038/s41531-023-00586-x

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