Cargando…
Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study
Primary pulmonary sarcoma (PPS) is a rare and poor prognostic malignancy that results from current clinical studies are lacking. Our study aimed to investigate the prognostic factors of PPS and to construct a predictive nomogram that predict the overall survival (OS) rate. We extracted data on patie...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584923/ https://www.ncbi.nlm.nih.gov/pubmed/37853232 http://dx.doi.org/10.1038/s41598-023-45058-7 |
_version_ | 1785122843807186944 |
---|---|
author | Huang, Qian Li, Wenqiang He, Xiaoyu He, Qian Lai, Qun Yuan, Quan Deng, Zhiping |
author_facet | Huang, Qian Li, Wenqiang He, Xiaoyu He, Qian Lai, Qun Yuan, Quan Deng, Zhiping |
author_sort | Huang, Qian |
collection | PubMed |
description | Primary pulmonary sarcoma (PPS) is a rare and poor prognostic malignancy that results from current clinical studies are lacking. Our study aimed to investigate the prognostic factors of PPS and to construct a predictive nomogram that predict the overall survival (OS) rate. We extracted data on patients diagnosed with PPS from 2010 to 2019 in the SEER database. A total of 169 patients were included after screening by inclusion and exclusion criteria. Univariate and multivariate COX regression analyses showed that age, pathological grade, liver metastasis, surgical intervention, and chemotherapy influenced the prognosis. We constructed the prediction model nomogram based on these factors. Moreover, the results of the internal and external ROC curves, calibration curves, and DCA plots confirmed that the model has good discrimination, accuracy, and clinical practice efficacy. The present study is the first population-based study to explore the factors affecting the prognosis of PPS. We established a novel prognostic nomogram to predict the OS rate, which can help to make proper clinical decisions. |
format | Online Article Text |
id | pubmed-10584923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105849232023-10-20 Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study Huang, Qian Li, Wenqiang He, Xiaoyu He, Qian Lai, Qun Yuan, Quan Deng, Zhiping Sci Rep Article Primary pulmonary sarcoma (PPS) is a rare and poor prognostic malignancy that results from current clinical studies are lacking. Our study aimed to investigate the prognostic factors of PPS and to construct a predictive nomogram that predict the overall survival (OS) rate. We extracted data on patients diagnosed with PPS from 2010 to 2019 in the SEER database. A total of 169 patients were included after screening by inclusion and exclusion criteria. Univariate and multivariate COX regression analyses showed that age, pathological grade, liver metastasis, surgical intervention, and chemotherapy influenced the prognosis. We constructed the prediction model nomogram based on these factors. Moreover, the results of the internal and external ROC curves, calibration curves, and DCA plots confirmed that the model has good discrimination, accuracy, and clinical practice efficacy. The present study is the first population-based study to explore the factors affecting the prognosis of PPS. We established a novel prognostic nomogram to predict the OS rate, which can help to make proper clinical decisions. Nature Publishing Group UK 2023-10-18 /pmc/articles/PMC10584923/ /pubmed/37853232 http://dx.doi.org/10.1038/s41598-023-45058-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Huang, Qian Li, Wenqiang He, Xiaoyu He, Qian Lai, Qun Yuan, Quan Deng, Zhiping Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study |
title | Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study |
title_full | Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study |
title_fullStr | Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study |
title_full_unstemmed | Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study |
title_short | Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study |
title_sort | prognostic visualization model for primary pulmonary sarcoma: a seer-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584923/ https://www.ncbi.nlm.nih.gov/pubmed/37853232 http://dx.doi.org/10.1038/s41598-023-45058-7 |
work_keys_str_mv | AT huangqian prognosticvisualizationmodelforprimarypulmonarysarcomaaseerbasedstudy AT liwenqiang prognosticvisualizationmodelforprimarypulmonarysarcomaaseerbasedstudy AT hexiaoyu prognosticvisualizationmodelforprimarypulmonarysarcomaaseerbasedstudy AT heqian prognosticvisualizationmodelforprimarypulmonarysarcomaaseerbasedstudy AT laiqun prognosticvisualizationmodelforprimarypulmonarysarcomaaseerbasedstudy AT yuanquan prognosticvisualizationmodelforprimarypulmonarysarcomaaseerbasedstudy AT dengzhiping prognosticvisualizationmodelforprimarypulmonarysarcomaaseerbasedstudy |