Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytes

Infection with high-risk human papillomaviruses like HPV-16 and HPV-18 is highly associated with the development of cervical and other cancers. Malignant transformation requires viral oncoproteins E5, E6 and E7, which promote cell proliferation and increase DNA damage. Oxidative stress and hypoxia a...

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Detalles Bibliográficos
Autores principales: Hochmann, Jimena, Millán, Magdalena, Hernández, Paola, Lafon-Hughes, Laura, Aiuto, Natali D’, Silva, Alejandro, Llaguno, Juan, Alonso, Julia, Fernández, Ariel, Pereira-Prado, Vanesa, Sotelo-Silveira, José, Bologna-Molina, Ronell, Arocena, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584980/
https://www.ncbi.nlm.nih.gov/pubmed/37853061
http://dx.doi.org/10.1038/s41598-023-44880-3

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