Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelling to determine whether pharmacokinetic and genetic variables...

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Detalles Bibliográficos
Autores principales: Lock, Siobhan K., Legge, Sophie E., Kappel, Djenifer B., Willcocks, Isabella R., Helthuis, Marinka, Jansen, John, Walters, James T. R., Owen, Michael J., O’Donovan, Michael C., Pardiñas, Antonio F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585000/
https://www.ncbi.nlm.nih.gov/pubmed/37853043
http://dx.doi.org/10.1038/s41537-023-00404-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585000/
https://www.ncbi.nlm.nih.gov/pubmed/37853043
http://dx.doi.org/10.1038/s41537-023-00404-6

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