Cargando…

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelling to determine whether pharmacokinetic and genetic variables...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lock, Siobhan K., Legge, Sophie E., Kappel, Djenifer B., Willcocks, Isabella R., Helthuis, Marinka, Jansen, John, Walters, James T. R., Owen, Michael J., O’Donovan, Michael C., Pardiñas, Antonio F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585000/ https://www.ncbi.nlm.nih.gov/pubmed/37853043 http://dx.doi.org/10.1038/s41537-023-00404-6

Ejemplares similares

Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia
por: Willcocks, Isabella R., et al.
Publicado: (2021)

The effect of COVID-19 on absolute neutrophil counts in patients taking clozapine
por: Gee, Siobhan, et al.
Publicado: (2020)

Reasons for discontinuing clozapine: A cohort study of patients commencing treatment
por: Legge, Sophie E., et al.
Publicado: (2016)

Reduction in Absolute Neutrophil Counts in Patient on Clozapine Infected with COVID-19
por: Ramli, Fitri Fareez, et al.
Publicado: (2021)

Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective
por: Legge, Sophie E, et al.
Publicado: (2019)

COVID-19 infection causes a reduction in neutrophil counts in patients taking clozapine
por: Gee, Siobhan, et al.
Publicado: (2021)

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis
por: Islam, Farhana, et al.
Publicado: (2022)

O9.1. SATISFACTION WITH USING A NOVEL FINGERSTICK FOR ABSOLUTE NEUTROPHIL COUNT (ANC) AT THE POINT OF TREATMENT IN PATIENTS TREATED WITH CLOZAPINE
por: Kelly, Deanna, et al.
Publicado: (2020)

»Treatment Resistance« Enigma Resolved by Pharmacogenomics - A Case Study of Clozapine Therapy in Schizophrenia
por: Marić, Nadja P., et al.
Publicado: (2015)

Clinical Indicators of Symptom Dimensions and Cognitive Ability in Schizophrenia
por: Farakish, L., et al.
Publicado: (2022)

Prognostic Significance of Absolute Lymphocyte Count/Absolute Monocyte Count Ratio at Diagnosis in Patients with Multiple Myeloma
por: Shin, Su-Jin, et al.
Publicado: (2013)

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
por: Legge, S E, et al.
Publicado: (2017)

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry
por: Konte, Bettina, et al.
Publicado: (2021)

Making IT count: strategy, delivery, infrastructure
por: Willcocks, Leslie
Publicado: (2002)

Clozapine and COVID-19
por: Silva, Edward, et al.
Publicado: (2020)

Erratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
por: Legge, S E, et al.
Publicado: (2017)

Erratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
por: Legge, S E, et al.
Publicado: (2016)

Pharmacist Consult Reports to Support Pharmacogenomics Report Interpretation
por: Bright, David, et al.
Publicado: (2020)

MAKED THROMBOCYTE COUNT VARIATIONS WITHOUT AGRANULOCTOSIS DUE TO CLOZAPINE
por: Savithasri Eranti, V., et al.
Publicado: (1998)

Low Multiplication Value of Absolute Monocyte Count and Absolute Lymphocyte Count at Diagnosis May Predict Poor Prognosis in Neuroblastoma
por: Tamura, Akihiro, et al.
Publicado: (2020)

S178. SHOULD SCHIZOAFFECTIVE DISORDER DEPRESSED-TYPE BE DISTINCT FROM SCHIZOPHRENIA? ANALYSIS OF GENETIC LIABILITY AND LIFETIME CLINICAL CHARACTERISTICS
por: Dennison, Charlotte, et al.
Publicado: (2020)

Beyond the bins: interpreting and discussing pharmacogenomic reports with psychiatric patients
por: Dunlop, Boadie W.
Publicado: (2020)

The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
por: Gharani, Neda, et al.
Publicado: (2013)

Clozapine and desmethylclozapine: correlation with neutrophils and leucocytes counting in Mexican patients with schizophrenia
por: Vaquero-Baez, Mayela, et al.
Publicado: (2019)

PB1744: THE RATIO OF ABSOLUTE LYMPHOCYTE COUNT AT INTERIM OF THERAPY TO ABSOLUTE LYMPHOCYTE COUNT AT DIAGNOSIS PREDICTS SURVIVAL IN ACUTE LYMPHOBLASTIC LEUKEMIA
por: Faiza, Talbi, et al.
Publicado: (2023)

Analysis of absolute lymphocyte count in patients with COVID-19
por: Illg, Zachary, et al.
Publicado: (2021)

TRUmiCount: correctly counting absolute numbers of molecules using unique molecular identifiers
por: Pflug, Florian G, et al.
Publicado: (2018)

Distinctive pattern of neutrophil count change in clozapine-associated, life-threatening agranulocytosis
por: Taylor, David, et al.
Publicado: (2022)

Inflammatory response to clozapine in the absence of myocarditis: case report
por: Davey, Patrick, et al.
Publicado: (2016)

Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis
por: Gambichler, T, et al.
Publicado: (2010)

Counting the Photons: Determining the Absolute Storage Capacity of Persistent Phosphors
por: Van der Heggen, David, et al.
Publicado: (2017)

Absolute lymphocyte and neutrophil counts in neonatal ischemic brain injury
por: Povroznik, Jessica M, et al.
Publicado: (2018)

Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: data-linkage study
por: Kendall, Kimberley M., et al.
Publicado: (2020)

PharmVIP: A Web-Based Tool for Pharmacogenomic Variant Analysis and Interpretation
por: Piriyapongsa, Jittima, et al.
Publicado: (2021)

Ultrarare Coding Variants and Cognitive Function in Schizophrenia
por: Creeth, Hugo D. J., et al.
Publicado: (2022)

Comparative Effects of Event Detection Methods on the Analysis and Interpretation of Ca(2+) Imaging Data
por: Neugornet, Austin, et al.
Publicado: (2021)

Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients
por: Kyllesø, Lennart, et al.
Publicado: (2021)

Associations between absolute neutrophil count and lymphocyte-predominant breast cancer
por: Yoon, Chang Ik, et al.
Publicado: (2019)

Prognostic Value of Preoperative Absolute Lymphocyte Count in Children With Tetralogy of Fallot
por: Wu, Xie, et al.
Publicado: (2021)

Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria
por: Barr, David A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_llrvm6rqkdvtcvsgadodl8jtq5