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Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones

Patients with Parkinson's disease (PD) exhibit distinct abnormal postures, including neck-down, stooped postures, and Pisa syndrome, collectively termed “abnormal posture” henceforth. In the previous study, when assuming an upright stance, patients with PD exhibit heightened instability in cont...

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Autores principales: Omura, Yuichiro, Togo, Hiroki, Kaminishi, Kohei, Hasegawa, Tetsuya, Chiba, Ryosuke, Yozu, Arito, Takakusaki, Kaoru, Abe, Mitsunari, Takahashi, Yuji, Hanakawa, Takashi, Ota, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585043/
https://www.ncbi.nlm.nih.gov/pubmed/37867918
http://dx.doi.org/10.3389/fncom.2023.1218707
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author Omura, Yuichiro
Togo, Hiroki
Kaminishi, Kohei
Hasegawa, Tetsuya
Chiba, Ryosuke
Yozu, Arito
Takakusaki, Kaoru
Abe, Mitsunari
Takahashi, Yuji
Hanakawa, Takashi
Ota, Jun
author_facet Omura, Yuichiro
Togo, Hiroki
Kaminishi, Kohei
Hasegawa, Tetsuya
Chiba, Ryosuke
Yozu, Arito
Takakusaki, Kaoru
Abe, Mitsunari
Takahashi, Yuji
Hanakawa, Takashi
Ota, Jun
author_sort Omura, Yuichiro
collection PubMed
description Patients with Parkinson's disease (PD) exhibit distinct abnormal postures, including neck-down, stooped postures, and Pisa syndrome, collectively termed “abnormal posture” henceforth. In the previous study, when assuming an upright stance, patients with PD exhibit heightened instability in contrast to healthy individuals with disturbance, implying that abnormal postures serve as compensatory mechanisms to mitigate sway during static standing. However, limited studies have explored the relationship between abnormal posture and sway in the context of static standing. Increased muscle tone (i.e., constant muscle activity against the gravity) has been proposed as an underlying reason for abnormal postures. Therefore, this study aimed to investigate the following hypothesis: abnormal posture with increased muscle tone leads to a smaller sway compared with that in other postures, including normal upright standing, under the sway minimization criterion. To investigate the hypothesis, we assessed the sway in multiple postures, which is determined by joint angles, including cases with bended hip joints. Our approach involved conducting forward dynamics simulations using a computational model comprising a musculoskeletal model and a neural controller model. The neural controller model proposed integrates two types of control mechanisms: feedforward control (representing muscle tone as a vector) and feedback control using proprioceptive and vestibular sensory information. An optimization was performed to determine the posture of the musculoskeletal model and the accompanied parameters of the neural controller model for each of the given muscle tone vector to minimize sway. The optimized postures to minimize sway for the optimal muscle tone vector of patients with PD were compared to the actual postures observed in these patients. The results revealed that on average, the joint-angle differences between these postures was <4°, which was less than one-tenth of the typical joint range of motion. These results suggest that patients with PD exhibit less sway in the abnormal posture than in other postures. Thus, adopting an abnormal posture with increased muscle tone can potentially serve as a valid strategy for minimizing sway in patients with PD.
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spelling pubmed-105850432023-10-20 Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones Omura, Yuichiro Togo, Hiroki Kaminishi, Kohei Hasegawa, Tetsuya Chiba, Ryosuke Yozu, Arito Takakusaki, Kaoru Abe, Mitsunari Takahashi, Yuji Hanakawa, Takashi Ota, Jun Front Comput Neurosci Neuroscience Patients with Parkinson's disease (PD) exhibit distinct abnormal postures, including neck-down, stooped postures, and Pisa syndrome, collectively termed “abnormal posture” henceforth. In the previous study, when assuming an upright stance, patients with PD exhibit heightened instability in contrast to healthy individuals with disturbance, implying that abnormal postures serve as compensatory mechanisms to mitigate sway during static standing. However, limited studies have explored the relationship between abnormal posture and sway in the context of static standing. Increased muscle tone (i.e., constant muscle activity against the gravity) has been proposed as an underlying reason for abnormal postures. Therefore, this study aimed to investigate the following hypothesis: abnormal posture with increased muscle tone leads to a smaller sway compared with that in other postures, including normal upright standing, under the sway minimization criterion. To investigate the hypothesis, we assessed the sway in multiple postures, which is determined by joint angles, including cases with bended hip joints. Our approach involved conducting forward dynamics simulations using a computational model comprising a musculoskeletal model and a neural controller model. The neural controller model proposed integrates two types of control mechanisms: feedforward control (representing muscle tone as a vector) and feedback control using proprioceptive and vestibular sensory information. An optimization was performed to determine the posture of the musculoskeletal model and the accompanied parameters of the neural controller model for each of the given muscle tone vector to minimize sway. The optimized postures to minimize sway for the optimal muscle tone vector of patients with PD were compared to the actual postures observed in these patients. The results revealed that on average, the joint-angle differences between these postures was <4°, which was less than one-tenth of the typical joint range of motion. These results suggest that patients with PD exhibit less sway in the abnormal posture than in other postures. Thus, adopting an abnormal posture with increased muscle tone can potentially serve as a valid strategy for minimizing sway in patients with PD. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10585043/ /pubmed/37867918 http://dx.doi.org/10.3389/fncom.2023.1218707 Text en Copyright © 2023 Omura, Togo, Kaminishi, Hasegawa, Chiba, Yozu, Takakusaki, Abe, Takahashi, Hanakawa and Ota. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Omura, Yuichiro
Togo, Hiroki
Kaminishi, Kohei
Hasegawa, Tetsuya
Chiba, Ryosuke
Yozu, Arito
Takakusaki, Kaoru
Abe, Mitsunari
Takahashi, Yuji
Hanakawa, Takashi
Ota, Jun
Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones
title Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones
title_full Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones
title_fullStr Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones
title_full_unstemmed Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones
title_short Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones
title_sort analysis of abnormal posture in patients with parkinson's disease using a computational model considering muscle tones
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585043/
https://www.ncbi.nlm.nih.gov/pubmed/37867918
http://dx.doi.org/10.3389/fncom.2023.1218707
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