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Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention

2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). A “cytokine storm”, i.e., elevated levels of pro-inflammatory cytokines in the bloodstream, has been observed in severe cases of COVID-19. Normally, activation of the nucl...

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Autores principales: Zhang, Jiayu, Ma, Xuejing, Liu, Fuwei, Zhang, Deju, Ling, Jitao, Zhu, Zicheng, Chen, Yixuan, Yang, Pingping, Yang, Yanlin, Liu, Xiao, Zhang, Jing, Liu, Jianping, Yu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585100/
https://www.ncbi.nlm.nih.gov/pubmed/37868953
http://dx.doi.org/10.3389/fimmu.2023.1203389
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author Zhang, Jiayu
Ma, Xuejing
Liu, Fuwei
Zhang, Deju
Ling, Jitao
Zhu, Zicheng
Chen, Yixuan
Yang, Pingping
Yang, Yanlin
Liu, Xiao
Zhang, Jing
Liu, Jianping
Yu, Peng
author_facet Zhang, Jiayu
Ma, Xuejing
Liu, Fuwei
Zhang, Deju
Ling, Jitao
Zhu, Zicheng
Chen, Yixuan
Yang, Pingping
Yang, Yanlin
Liu, Xiao
Zhang, Jing
Liu, Jianping
Yu, Peng
author_sort Zhang, Jiayu
collection PubMed
description 2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). A “cytokine storm”, i.e., elevated levels of pro-inflammatory cytokines in the bloodstream, has been observed in severe cases of COVID-19. Normally, activation of the nucleotide-binding oligomeric domain-like receptor containing pyrin domain 3 (NLRP3) inflammatory vesicles induces cytokine production as an inflammatory response to viral infection. Recent studies have found an increased severity of necrobiosis infection in diabetic patients, and data from several countries have shown higher morbidity and mortality of necrobiosis in people with chronic metabolic diseases such as diabetes. In addition, COVID-19 may also predispose infected individuals to hyperglycemia. Therefore, in this review, we explore the potential relationship between NLRP3 inflammatory vesicles in diabetes and COVID-19. In contrast, we review the cellular/molecular mechanisms by which SARS-CoV-2 infection activates NLRP3 inflammatory vesicles. Finally, we propose several promising targeted NLRP3 inflammatory vesicle inhibitors with the aim of providing a basis for NLRP3-targeted drugs in diabetes combined with noncoronary pneumonia in the clinical management of patients.
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spelling pubmed-105851002023-10-20 Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention Zhang, Jiayu Ma, Xuejing Liu, Fuwei Zhang, Deju Ling, Jitao Zhu, Zicheng Chen, Yixuan Yang, Pingping Yang, Yanlin Liu, Xiao Zhang, Jing Liu, Jianping Yu, Peng Front Immunol Immunology 2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). A “cytokine storm”, i.e., elevated levels of pro-inflammatory cytokines in the bloodstream, has been observed in severe cases of COVID-19. Normally, activation of the nucleotide-binding oligomeric domain-like receptor containing pyrin domain 3 (NLRP3) inflammatory vesicles induces cytokine production as an inflammatory response to viral infection. Recent studies have found an increased severity of necrobiosis infection in diabetic patients, and data from several countries have shown higher morbidity and mortality of necrobiosis in people with chronic metabolic diseases such as diabetes. In addition, COVID-19 may also predispose infected individuals to hyperglycemia. Therefore, in this review, we explore the potential relationship between NLRP3 inflammatory vesicles in diabetes and COVID-19. In contrast, we review the cellular/molecular mechanisms by which SARS-CoV-2 infection activates NLRP3 inflammatory vesicles. Finally, we propose several promising targeted NLRP3 inflammatory vesicle inhibitors with the aim of providing a basis for NLRP3-targeted drugs in diabetes combined with noncoronary pneumonia in the clinical management of patients. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10585100/ /pubmed/37868953 http://dx.doi.org/10.3389/fimmu.2023.1203389 Text en Copyright © 2023 Zhang, Ma, Liu, Zhang, Ling, Zhu, Chen, Yang, Yang, Liu, Zhang, Liu and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Jiayu
Ma, Xuejing
Liu, Fuwei
Zhang, Deju
Ling, Jitao
Zhu, Zicheng
Chen, Yixuan
Yang, Pingping
Yang, Yanlin
Liu, Xiao
Zhang, Jing
Liu, Jianping
Yu, Peng
Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention
title Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention
title_full Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention
title_fullStr Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention
title_full_unstemmed Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention
title_short Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention
title_sort role of nlrp3 inflammasome in diabetes and covid-19 role of nlrp3 inflammasome in the pathogenesis and treatment of covid-19 and diabetes nlrp3 inflammasome in diabetes and covid-19 intervention
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585100/
https://www.ncbi.nlm.nih.gov/pubmed/37868953
http://dx.doi.org/10.3389/fimmu.2023.1203389
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