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Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game
Aerobic glycolysis, also known as the Warburg effect, has for a prolonged period of time been perceived as a defining feature of tumor metabolism. The redirection of glucose utilization towards increased production of lactate by cancer cells enables their rapid proliferation, unceasing growth, and l...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585168/ https://www.ncbi.nlm.nih.gov/pubmed/37868977 http://dx.doi.org/10.3389/fimmu.2023.1236301 |
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author | Marciniak, Mateusz Wagner, Marek |
author_facet | Marciniak, Mateusz Wagner, Marek |
author_sort | Marciniak, Mateusz |
collection | PubMed |
description | Aerobic glycolysis, also known as the Warburg effect, has for a prolonged period of time been perceived as a defining feature of tumor metabolism. The redirection of glucose utilization towards increased production of lactate by cancer cells enables their rapid proliferation, unceasing growth, and longevity. At the same time, it serves as a significant contributor to acidification of the tumor microenvironment, which, in turn, imposes substantial constraints on infiltrating immune cells. Here, we delve into the influence of tumor-derived lactic acid on innate lymphoid cells (ILCs) and discuss potential therapeutic approaches. Given the abundance of ILCs in barrier tissues such as the skin, we provide insights aimed at translating this knowledge into therapies that may specifically target skin cancer. |
format | Online Article Text |
id | pubmed-10585168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105851682023-10-20 Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game Marciniak, Mateusz Wagner, Marek Front Immunol Immunology Aerobic glycolysis, also known as the Warburg effect, has for a prolonged period of time been perceived as a defining feature of tumor metabolism. The redirection of glucose utilization towards increased production of lactate by cancer cells enables their rapid proliferation, unceasing growth, and longevity. At the same time, it serves as a significant contributor to acidification of the tumor microenvironment, which, in turn, imposes substantial constraints on infiltrating immune cells. Here, we delve into the influence of tumor-derived lactic acid on innate lymphoid cells (ILCs) and discuss potential therapeutic approaches. Given the abundance of ILCs in barrier tissues such as the skin, we provide insights aimed at translating this knowledge into therapies that may specifically target skin cancer. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10585168/ /pubmed/37868977 http://dx.doi.org/10.3389/fimmu.2023.1236301 Text en Copyright © 2023 Marciniak and Wagner https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Marciniak, Mateusz Wagner, Marek Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game |
title | Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game |
title_full | Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game |
title_fullStr | Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game |
title_full_unstemmed | Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game |
title_short | Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game |
title_sort | innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585168/ https://www.ncbi.nlm.nih.gov/pubmed/37868977 http://dx.doi.org/10.3389/fimmu.2023.1236301 |
work_keys_str_mv | AT marciniakmateusz innatelymphoidcellsandtumorderivedlacticacidnovelcontendersinanenduringgame AT wagnermarek innatelymphoidcellsandtumorderivedlacticacidnovelcontendersinanenduringgame |