Cargando…

An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk

Asthma is a common disease that seriously threatens public health. With significant developments in bronchoscopy, different interventional pulmonology techniques for refractory asthma treatment have been developed. These technologies achieve therapeutic purposes by targeting diverse aspects of asthm...

Descripción completa

Detalles Bibliográficos
Autores principales: Liao, Ximing, Gao, Shaoyong, Xie, Fengyang, Wang, Kun, Wu, Xiaodong, Wu, Yin, Gao, Wei, Wang, Muyun, Sun, Jiaxing, Liu, Dongchen, Xu, Wujian, Li, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585236/
https://www.ncbi.nlm.nih.gov/pubmed/37867902
http://dx.doi.org/10.1016/j.heliyon.2023.e20797
_version_ 1785122910963236864
author Liao, Ximing
Gao, Shaoyong
Xie, Fengyang
Wang, Kun
Wu, Xiaodong
Wu, Yin
Gao, Wei
Wang, Muyun
Sun, Jiaxing
Liu, Dongchen
Xu, Wujian
Li, Qiang
author_facet Liao, Ximing
Gao, Shaoyong
Xie, Fengyang
Wang, Kun
Wu, Xiaodong
Wu, Yin
Gao, Wei
Wang, Muyun
Sun, Jiaxing
Liu, Dongchen
Xu, Wujian
Li, Qiang
author_sort Liao, Ximing
collection PubMed
description Asthma is a common disease that seriously threatens public health. With significant developments in bronchoscopy, different interventional pulmonology techniques for refractory asthma treatment have been developed. These technologies achieve therapeutic purposes by targeting diverse aspects of asthma pathophysiology. However, even though these newer techniques have shown appreciable clinical effects, their differences in mechanisms and mutual commonalities still deserve to be carefully explored. Therefore, in this review, we summarized the potential mechanisms of bronchial thermoplasty, targeted lung denervation, and cryoablation, and analyzed the relationship between these different methods. Based on available evidence, we speculated that the main pathway of chronic airway inflammation and other pathophysiologic processes in asthma is sensory nerve-related neurotransmitter release that forms a “neuro-immunity crosstalk” and amplifies airway neurogenic inflammation. The mechanism of completely blocking neuro-immunity crosstalk through dual-ablation of both efferent and afferent fibers may have a leading role in the clinical efficacy of interventional pulmonology in the treatment of asthma and deserves further investigation.
format Online
Article
Text
id pubmed-10585236
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105852362023-10-20 An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk Liao, Ximing Gao, Shaoyong Xie, Fengyang Wang, Kun Wu, Xiaodong Wu, Yin Gao, Wei Wang, Muyun Sun, Jiaxing Liu, Dongchen Xu, Wujian Li, Qiang Heliyon Review Article Asthma is a common disease that seriously threatens public health. With significant developments in bronchoscopy, different interventional pulmonology techniques for refractory asthma treatment have been developed. These technologies achieve therapeutic purposes by targeting diverse aspects of asthma pathophysiology. However, even though these newer techniques have shown appreciable clinical effects, their differences in mechanisms and mutual commonalities still deserve to be carefully explored. Therefore, in this review, we summarized the potential mechanisms of bronchial thermoplasty, targeted lung denervation, and cryoablation, and analyzed the relationship between these different methods. Based on available evidence, we speculated that the main pathway of chronic airway inflammation and other pathophysiologic processes in asthma is sensory nerve-related neurotransmitter release that forms a “neuro-immunity crosstalk” and amplifies airway neurogenic inflammation. The mechanism of completely blocking neuro-immunity crosstalk through dual-ablation of both efferent and afferent fibers may have a leading role in the clinical efficacy of interventional pulmonology in the treatment of asthma and deserves further investigation. Elsevier 2023-10-10 /pmc/articles/PMC10585236/ /pubmed/37867902 http://dx.doi.org/10.1016/j.heliyon.2023.e20797 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Liao, Ximing
Gao, Shaoyong
Xie, Fengyang
Wang, Kun
Wu, Xiaodong
Wu, Yin
Gao, Wei
Wang, Muyun
Sun, Jiaxing
Liu, Dongchen
Xu, Wujian
Li, Qiang
An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
title An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
title_full An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
title_fullStr An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
title_full_unstemmed An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
title_short An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
title_sort underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: neuro-immunity crosstalk
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585236/
https://www.ncbi.nlm.nih.gov/pubmed/37867902
http://dx.doi.org/10.1016/j.heliyon.2023.e20797
work_keys_str_mv AT liaoximing anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT gaoshaoyong anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT xiefengyang anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wangkun anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wuxiaodong anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wuyin anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT gaowei anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wangmuyun anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT sunjiaxing anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT liudongchen anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT xuwujian anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT liqiang anunderlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT liaoximing underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT gaoshaoyong underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT xiefengyang underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wangkun underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wuxiaodong underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wuyin underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT gaowei underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT wangmuyun underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT sunjiaxing underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT liudongchen underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT xuwujian underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk
AT liqiang underlyingmechanismbehindinterventionalpulmonologytechniquesforrefractoryasthmatreatmentneuroimmunitycrosstalk