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An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
Asthma is a common disease that seriously threatens public health. With significant developments in bronchoscopy, different interventional pulmonology techniques for refractory asthma treatment have been developed. These technologies achieve therapeutic purposes by targeting diverse aspects of asthm...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585236/ https://www.ncbi.nlm.nih.gov/pubmed/37867902 http://dx.doi.org/10.1016/j.heliyon.2023.e20797 |
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author | Liao, Ximing Gao, Shaoyong Xie, Fengyang Wang, Kun Wu, Xiaodong Wu, Yin Gao, Wei Wang, Muyun Sun, Jiaxing Liu, Dongchen Xu, Wujian Li, Qiang |
author_facet | Liao, Ximing Gao, Shaoyong Xie, Fengyang Wang, Kun Wu, Xiaodong Wu, Yin Gao, Wei Wang, Muyun Sun, Jiaxing Liu, Dongchen Xu, Wujian Li, Qiang |
author_sort | Liao, Ximing |
collection | PubMed |
description | Asthma is a common disease that seriously threatens public health. With significant developments in bronchoscopy, different interventional pulmonology techniques for refractory asthma treatment have been developed. These technologies achieve therapeutic purposes by targeting diverse aspects of asthma pathophysiology. However, even though these newer techniques have shown appreciable clinical effects, their differences in mechanisms and mutual commonalities still deserve to be carefully explored. Therefore, in this review, we summarized the potential mechanisms of bronchial thermoplasty, targeted lung denervation, and cryoablation, and analyzed the relationship between these different methods. Based on available evidence, we speculated that the main pathway of chronic airway inflammation and other pathophysiologic processes in asthma is sensory nerve-related neurotransmitter release that forms a “neuro-immunity crosstalk” and amplifies airway neurogenic inflammation. The mechanism of completely blocking neuro-immunity crosstalk through dual-ablation of both efferent and afferent fibers may have a leading role in the clinical efficacy of interventional pulmonology in the treatment of asthma and deserves further investigation. |
format | Online Article Text |
id | pubmed-10585236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105852362023-10-20 An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk Liao, Ximing Gao, Shaoyong Xie, Fengyang Wang, Kun Wu, Xiaodong Wu, Yin Gao, Wei Wang, Muyun Sun, Jiaxing Liu, Dongchen Xu, Wujian Li, Qiang Heliyon Review Article Asthma is a common disease that seriously threatens public health. With significant developments in bronchoscopy, different interventional pulmonology techniques for refractory asthma treatment have been developed. These technologies achieve therapeutic purposes by targeting diverse aspects of asthma pathophysiology. However, even though these newer techniques have shown appreciable clinical effects, their differences in mechanisms and mutual commonalities still deserve to be carefully explored. Therefore, in this review, we summarized the potential mechanisms of bronchial thermoplasty, targeted lung denervation, and cryoablation, and analyzed the relationship between these different methods. Based on available evidence, we speculated that the main pathway of chronic airway inflammation and other pathophysiologic processes in asthma is sensory nerve-related neurotransmitter release that forms a “neuro-immunity crosstalk” and amplifies airway neurogenic inflammation. The mechanism of completely blocking neuro-immunity crosstalk through dual-ablation of both efferent and afferent fibers may have a leading role in the clinical efficacy of interventional pulmonology in the treatment of asthma and deserves further investigation. Elsevier 2023-10-10 /pmc/articles/PMC10585236/ /pubmed/37867902 http://dx.doi.org/10.1016/j.heliyon.2023.e20797 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Liao, Ximing Gao, Shaoyong Xie, Fengyang Wang, Kun Wu, Xiaodong Wu, Yin Gao, Wei Wang, Muyun Sun, Jiaxing Liu, Dongchen Xu, Wujian Li, Qiang An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk |
title | An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk |
title_full | An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk |
title_fullStr | An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk |
title_full_unstemmed | An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk |
title_short | An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk |
title_sort | underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: neuro-immunity crosstalk |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585236/ https://www.ncbi.nlm.nih.gov/pubmed/37867902 http://dx.doi.org/10.1016/j.heliyon.2023.e20797 |
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