The role of TRIM family in metabolic associated fatty liver disease

Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated. Tripartite motif (TRIM) protein is a kind of protein with E3 ubiquitin ligase activity, which participates in highly di...

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Autores principales: Zhang, Jingyue, Zhang, Yingming, Ren, Ze, Yan, Dongmei, Li, Guiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585262/
https://www.ncbi.nlm.nih.gov/pubmed/37867509
http://dx.doi.org/10.3389/fendo.2023.1210330
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author Zhang, Jingyue
Zhang, Yingming
Ren, Ze
Yan, Dongmei
Li, Guiying
author_facet Zhang, Jingyue
Zhang, Yingming
Ren, Ze
Yan, Dongmei
Li, Guiying
author_sort Zhang, Jingyue
collection PubMed
description Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated. Tripartite motif (TRIM) protein is a kind of protein with E3 ubiquitin ligase activity, which participates in highly diversified cell activities and processes. It not only plays an important role in innate immunity, but also participates in liver steatosis, insulin resistance and other processes. In this review, we focused on the role of TRIM family in metabolic associated fatty liver disease. We also introduced the structure and functions of TRIM proteins. We summarized the TRIM family’s regulation involved in the occurrence and development of metabolic associated fatty liver disease, as well as insulin resistance. We deeply discussed the potential of TRIM proteins as targets for the treatment of metabolic associated fatty liver disease.
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spelling pubmed-105852622023-10-20 The role of TRIM family in metabolic associated fatty liver disease Zhang, Jingyue Zhang, Yingming Ren, Ze Yan, Dongmei Li, Guiying Front Endocrinol (Lausanne) Endocrinology Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated. Tripartite motif (TRIM) protein is a kind of protein with E3 ubiquitin ligase activity, which participates in highly diversified cell activities and processes. It not only plays an important role in innate immunity, but also participates in liver steatosis, insulin resistance and other processes. In this review, we focused on the role of TRIM family in metabolic associated fatty liver disease. We also introduced the structure and functions of TRIM proteins. We summarized the TRIM family’s regulation involved in the occurrence and development of metabolic associated fatty liver disease, as well as insulin resistance. We deeply discussed the potential of TRIM proteins as targets for the treatment of metabolic associated fatty liver disease. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10585262/ /pubmed/37867509 http://dx.doi.org/10.3389/fendo.2023.1210330 Text en Copyright © 2023 Zhang, Zhang, Ren, Yan and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhang, Jingyue
Zhang, Yingming
Ren, Ze
Yan, Dongmei
Li, Guiying
The role of TRIM family in metabolic associated fatty liver disease
title The role of TRIM family in metabolic associated fatty liver disease
title_full The role of TRIM family in metabolic associated fatty liver disease
title_fullStr The role of TRIM family in metabolic associated fatty liver disease
title_full_unstemmed The role of TRIM family in metabolic associated fatty liver disease
title_short The role of TRIM family in metabolic associated fatty liver disease
title_sort role of trim family in metabolic associated fatty liver disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585262/
https://www.ncbi.nlm.nih.gov/pubmed/37867509
http://dx.doi.org/10.3389/fendo.2023.1210330
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