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Application of optogenetic glial cells to neuron–glial communication
Optogenetic techniques combine optics and genetics to enable cell-specific targeting and precise spatiotemporal control of excitable cells, and they are increasingly being employed. One of the most significant advantages of the optogenetic approach is that it allows for the modulation of nearby cell...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585272/ https://www.ncbi.nlm.nih.gov/pubmed/37868193 http://dx.doi.org/10.3389/fncel.2023.1249043 |
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author | Hyung, Sujin Park, Ji-Hye Jung, Kyuhwan |
author_facet | Hyung, Sujin Park, Ji-Hye Jung, Kyuhwan |
author_sort | Hyung, Sujin |
collection | PubMed |
description | Optogenetic techniques combine optics and genetics to enable cell-specific targeting and precise spatiotemporal control of excitable cells, and they are increasingly being employed. One of the most significant advantages of the optogenetic approach is that it allows for the modulation of nearby cells or circuits with millisecond precision, enabling researchers to gain a better understanding of the complex nervous system. Furthermore, optogenetic neuron activation permits the regulation of information processing in the brain, including synaptic activity and transmission, and also promotes nerve structure development. However, the optimal conditions remain unclear, and further research is required to identify the types of cells that can most effectively and precisely control nerve function. Recent studies have described optogenetic glial manipulation for coordinating the reciprocal communication between neurons and glia. Optogenetically stimulated glial cells can modulate information processing in the central nervous system and provide structural support for nerve fibers in the peripheral nervous system. These advances promote the effective use of optogenetics, although further experiments are needed. This review describes the critical role of glial cells in the nervous system and reviews the optogenetic applications of several types of glial cells, as well as their significance in neuron–glia interactions. Together, it briefly discusses the therapeutic potential and feasibility of optogenetics. |
format | Online Article Text |
id | pubmed-10585272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105852722023-10-20 Application of optogenetic glial cells to neuron–glial communication Hyung, Sujin Park, Ji-Hye Jung, Kyuhwan Front Cell Neurosci Cellular Neuroscience Optogenetic techniques combine optics and genetics to enable cell-specific targeting and precise spatiotemporal control of excitable cells, and they are increasingly being employed. One of the most significant advantages of the optogenetic approach is that it allows for the modulation of nearby cells or circuits with millisecond precision, enabling researchers to gain a better understanding of the complex nervous system. Furthermore, optogenetic neuron activation permits the regulation of information processing in the brain, including synaptic activity and transmission, and also promotes nerve structure development. However, the optimal conditions remain unclear, and further research is required to identify the types of cells that can most effectively and precisely control nerve function. Recent studies have described optogenetic glial manipulation for coordinating the reciprocal communication between neurons and glia. Optogenetically stimulated glial cells can modulate information processing in the central nervous system and provide structural support for nerve fibers in the peripheral nervous system. These advances promote the effective use of optogenetics, although further experiments are needed. This review describes the critical role of glial cells in the nervous system and reviews the optogenetic applications of several types of glial cells, as well as their significance in neuron–glia interactions. Together, it briefly discusses the therapeutic potential and feasibility of optogenetics. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10585272/ /pubmed/37868193 http://dx.doi.org/10.3389/fncel.2023.1249043 Text en Copyright © 2023 Hyung, Park and Jung. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Hyung, Sujin Park, Ji-Hye Jung, Kyuhwan Application of optogenetic glial cells to neuron–glial communication |
title | Application of optogenetic glial cells to neuron–glial communication |
title_full | Application of optogenetic glial cells to neuron–glial communication |
title_fullStr | Application of optogenetic glial cells to neuron–glial communication |
title_full_unstemmed | Application of optogenetic glial cells to neuron–glial communication |
title_short | Application of optogenetic glial cells to neuron–glial communication |
title_sort | application of optogenetic glial cells to neuron–glial communication |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585272/ https://www.ncbi.nlm.nih.gov/pubmed/37868193 http://dx.doi.org/10.3389/fncel.2023.1249043 |
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