Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates

Current immunotherapeutic targets are often shared between neoplastic and normal hematopoietic stem and progenitor cells (HSPCs), leading to unwanted on-target, off-tumor toxicities. Deletion or modification of such targets to protect normal HSPCs is, therefore, of great interest. Although HSPC modi...

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Detalles Bibliográficos
Autores principales: Petty, Nicholas E., Radtke, Stefan, Fields, Emily, Humbert, Olivier, Llewellyn, Mallory J., Laszlo, George S., Zhu, Haiying, Jerome, Keith R., Walter, Roland B., Kiem, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585325/
https://www.ncbi.nlm.nih.gov/pubmed/37868209
http://dx.doi.org/10.1016/j.omtm.2023.101121

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