Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells

INTRODUCTION: Despite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains poor. There is thus a strong need for better identifying local immune dynamics and immune-suppressive pathways limiting T-cell mediated anti-t...

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Detalles Bibliográficos
Autores principales: Tassi, Elena, Bergamini, Alice, Wignall, Jessica, Sant’Angelo, Miriam, Brunetto, Emanuela, Balestrieri, Chiara, Redegalli, Miriam, Potenza, Alessia, Abbati, Danilo, Manfredi, Francesco, Cangi, Maria Giulia, Magliacane, Gilda, Scalisi, Fabiola, Ruggiero, Eliana, Maffia, Maria Chiara, Trippitelli, Federica, Rabaiotti, Emanuela, Cioffi, Raffaella, Bocciolone, Luca, Candotti, Giorgio, Candiani, Massimo, Taccagni, Gianluca, Schultes, Birgit, Doglioni, Claudio, Mangili, Giorgia, Bonini, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585363/
https://www.ncbi.nlm.nih.gov/pubmed/37868997
http://dx.doi.org/10.3389/fimmu.2023.1212444

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