Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis

IMPORTANCE: Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are influenced by additional genetic factors. Despite decades of research, the genetics of SCD remain poorly understood. OBJECTIVE: To assess all reported genetic modifiers of SCD, evaluate the design of associated...

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Detalles Bibliográficos
Autores principales: Kirkham, Justin K., Estepp, Jeremie H., Weiss, Mitch J., Rashkin, Sara R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585422/
https://www.ncbi.nlm.nih.gov/pubmed/37851445
http://dx.doi.org/10.1001/jamanetworkopen.2023.37484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585422/
https://www.ncbi.nlm.nih.gov/pubmed/37851445
http://dx.doi.org/10.1001/jamanetworkopen.2023.37484

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