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Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study

BACKGROUND: This study aimed to investigate the prescription of traditional herbal medicines for the treatment of unexplained female infertility in Korea. By analyzing the relationships among the prescriptions and between the prescriptions and treatment outcomes, we aimed to confirm the utilization...

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Autores principales: Choi, Su-Ji, Kim, Dong-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585731/
https://www.ncbi.nlm.nih.gov/pubmed/37858191
http://dx.doi.org/10.1186/s12906-023-04192-5
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author Choi, Su-Ji
Kim, Dong-Il
author_facet Choi, Su-Ji
Kim, Dong-Il
author_sort Choi, Su-Ji
collection PubMed
description BACKGROUND: This study aimed to investigate the prescription of traditional herbal medicines for the treatment of unexplained female infertility in Korea. By analyzing the relationships among the prescriptions and between the prescriptions and treatment outcomes, we aimed to confirm the utilization of standardized prescriptions and the effectiveness of this standardization. METHODS: The data were derived from the “support projects” of the local government for infertile women to receive Korean medical treatments. The presciption data of 453 participants from 2017 to 2018 were analyzed. Data preprocessing, frequency analysis, and network analysis were conducted. For network analysis, the characteristics of the herbal medicine prescriptions were used to calculate the degree centrality, closeness centrality and eigenvector centrality. Modularity clustering was also performed for cluster analysis. RESULTS: Fifty different prescriptions were used, among which only 22 were used for participants who became pregnant. The recommended standard prescriptions for support projects were used frequently. “BaeranChacksangBang” showed the highest level of in-degree centrality. Among the prescriptions for participants who became pregnant, “JogyeongJongokTang” and “BaeranChacksangBang” were the most influential nodes. “BaeranChacksangBang”, “AnjeonYicheonTang”, “YukLinZu” and “JogyeongJongokTang” had high closeness centrality among the prescriptions for participants who became pregnant. Clustering analysis of the prescriptions for participants who became pregnant revealed that the prescriptions showed the best modularity when divided into five groups. CONCLUSIONS: These findings depict the utilization of Korean herbal medicine in the real world and the dynamics underlying the herbal medicine prescription patterns for infertile women. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12906-023-04192-5.
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spelling pubmed-105857312023-10-20 Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study Choi, Su-Ji Kim, Dong-Il BMC Complement Med Ther Research BACKGROUND: This study aimed to investigate the prescription of traditional herbal medicines for the treatment of unexplained female infertility in Korea. By analyzing the relationships among the prescriptions and between the prescriptions and treatment outcomes, we aimed to confirm the utilization of standardized prescriptions and the effectiveness of this standardization. METHODS: The data were derived from the “support projects” of the local government for infertile women to receive Korean medical treatments. The presciption data of 453 participants from 2017 to 2018 were analyzed. Data preprocessing, frequency analysis, and network analysis were conducted. For network analysis, the characteristics of the herbal medicine prescriptions were used to calculate the degree centrality, closeness centrality and eigenvector centrality. Modularity clustering was also performed for cluster analysis. RESULTS: Fifty different prescriptions were used, among which only 22 were used for participants who became pregnant. The recommended standard prescriptions for support projects were used frequently. “BaeranChacksangBang” showed the highest level of in-degree centrality. Among the prescriptions for participants who became pregnant, “JogyeongJongokTang” and “BaeranChacksangBang” were the most influential nodes. “BaeranChacksangBang”, “AnjeonYicheonTang”, “YukLinZu” and “JogyeongJongokTang” had high closeness centrality among the prescriptions for participants who became pregnant. Clustering analysis of the prescriptions for participants who became pregnant revealed that the prescriptions showed the best modularity when divided into five groups. CONCLUSIONS: These findings depict the utilization of Korean herbal medicine in the real world and the dynamics underlying the herbal medicine prescription patterns for infertile women. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12906-023-04192-5. BioMed Central 2023-10-19 /pmc/articles/PMC10585731/ /pubmed/37858191 http://dx.doi.org/10.1186/s12906-023-04192-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Choi, Su-Ji
Kim, Dong-Il
Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study
title Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study
title_full Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study
title_fullStr Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study
title_full_unstemmed Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study
title_short Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study
title_sort utilization of traditional herbal medicine formulas for unexplained female infertility in korea: a retrospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585731/
https://www.ncbi.nlm.nih.gov/pubmed/37858191
http://dx.doi.org/10.1186/s12906-023-04192-5
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