Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in Alzheimer’s disease (AD). The protein expression level of TTBK1 is elevated in the cortex brain tissues with AD patients compared to...

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Detalles Bibliográficos
Autores principales: Yukawa, Kayo, Yamamoto-Mcguire, Satomi, Cafaro, Louis, Hong, Christine, Kamme, Fredrik, Ikezu, Tsuneya, Ikezu, Seiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585748/
https://www.ncbi.nlm.nih.gov/pubmed/37853497
http://dx.doi.org/10.1186/s40478-023-01661-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585748/
https://www.ncbi.nlm.nih.gov/pubmed/37853497
http://dx.doi.org/10.1186/s40478-023-01661-3

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