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A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice

BACKGROUND: APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is greater in females. Evidence suggests that one-way APOE could modulate AD risk and progression through neuroinflammation. In...

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Detalles Bibliográficos
Autores principales:	Balu, Deebika, Valencia-Olvera, Ana C., Nguyen, Austin, Patnam, Mehul, York, Jason, Peri, Francesco, Neumann, Frank, LaDu, Mary Jo, Tai, Leon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585767/ https://www.ncbi.nlm.nih.gov/pubmed/37858252 http://dx.doi.org/10.1186/s13195-023-01330-6

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