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Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study
PURPOSE: To investigate foveal changes in infants with ROP not requiring treatment(nROP) and ROP infants needing treatment (tROP) using a handheld SD-OCT device. METHOD: We performed horizontal SD-OCT scans through the fovea in 156 eyes of 81 infants diagnosed with ROP. Foveal immaturity indices inc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585878/ https://www.ncbi.nlm.nih.gov/pubmed/37853491 http://dx.doi.org/10.1186/s40942-023-00499-0 |
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author | Bazvand, Fatemeh Salari, Farhad Barzi, Navid Hasani Ghassemi, Fariba Maleki, Anahid Dastjani Farahani, Afsar Imani Fooladi, Marjan Taleghani, Naeeme Taslimi Shariati, Maryam Khoshnoud Harper, C. Armitage Mehrabi Bahar, Mohammadreza |
author_facet | Bazvand, Fatemeh Salari, Farhad Barzi, Navid Hasani Ghassemi, Fariba Maleki, Anahid Dastjani Farahani, Afsar Imani Fooladi, Marjan Taleghani, Naeeme Taslimi Shariati, Maryam Khoshnoud Harper, C. Armitage Mehrabi Bahar, Mohammadreza |
author_sort | Bazvand, Fatemeh |
collection | PubMed |
description | PURPOSE: To investigate foveal changes in infants with ROP not requiring treatment(nROP) and ROP infants needing treatment (tROP) using a handheld SD-OCT device. METHOD: We performed horizontal SD-OCT scans through the fovea in 156 eyes of 81 infants diagnosed with ROP. Foveal immaturity indices including the presence of inner retinal layers (IRL), absence of foveal outer nuclear layers widening (ONL) and attenuation of hyperreflective outer segment layers (OS), presence and type of cystoid macular edema (CME), epiretinal membrane (ERM), foveal pit depth (FPD), foveal pit width (FPW) and central foveal thickness (CFT) were calculated. The multivariate logistic regression model was used to predict the need for treatment based on OCT measurements. RESULTS: The shape of the foveolar pit was not significantly different among tROP and nROP groups (P-value = 0.287, Chi-square test). IRL extrusion was incomplete in both tROP and nROP groups (P-value = 0.0.41, Chi-square test). Nevertheless, the presence of thicker IRL was more frequent in the nROP group in comparison with the tROP group (100% vs.64.8%, P-value = 0.001). CME was observed in 29% of eyes in the tROP group and 40% of eyes in the nROP group; however, this difference was not statistically significant (P-value = 0.32, Chi-square test). ERM was detected in 15 (75%) and 84 (65.6%) eyes in the nROP and tROP groups, respectively (P-value = 0.39, Chi-square test). Multivariate logistic regression analyses showed that the need for treatment was significantly associated with gestational age (GA), CFT and FPD (P-values 0.001 and 0.002 respectively). CONCLUSIONS: This study demonstrated GA, foveal pit depth and the central foveal thickness could accurately predict the need for treatment with sensitivity, specificity, and diagnostic accuracy of 97%, 65% and 91.7% respectively. |
format | Online Article Text |
id | pubmed-10585878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105858782023-10-20 Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study Bazvand, Fatemeh Salari, Farhad Barzi, Navid Hasani Ghassemi, Fariba Maleki, Anahid Dastjani Farahani, Afsar Imani Fooladi, Marjan Taleghani, Naeeme Taslimi Shariati, Maryam Khoshnoud Harper, C. Armitage Mehrabi Bahar, Mohammadreza Int J Retina Vitreous Original Article PURPOSE: To investigate foveal changes in infants with ROP not requiring treatment(nROP) and ROP infants needing treatment (tROP) using a handheld SD-OCT device. METHOD: We performed horizontal SD-OCT scans through the fovea in 156 eyes of 81 infants diagnosed with ROP. Foveal immaturity indices including the presence of inner retinal layers (IRL), absence of foveal outer nuclear layers widening (ONL) and attenuation of hyperreflective outer segment layers (OS), presence and type of cystoid macular edema (CME), epiretinal membrane (ERM), foveal pit depth (FPD), foveal pit width (FPW) and central foveal thickness (CFT) were calculated. The multivariate logistic regression model was used to predict the need for treatment based on OCT measurements. RESULTS: The shape of the foveolar pit was not significantly different among tROP and nROP groups (P-value = 0.287, Chi-square test). IRL extrusion was incomplete in both tROP and nROP groups (P-value = 0.0.41, Chi-square test). Nevertheless, the presence of thicker IRL was more frequent in the nROP group in comparison with the tROP group (100% vs.64.8%, P-value = 0.001). CME was observed in 29% of eyes in the tROP group and 40% of eyes in the nROP group; however, this difference was not statistically significant (P-value = 0.32, Chi-square test). ERM was detected in 15 (75%) and 84 (65.6%) eyes in the nROP and tROP groups, respectively (P-value = 0.39, Chi-square test). Multivariate logistic regression analyses showed that the need for treatment was significantly associated with gestational age (GA), CFT and FPD (P-values 0.001 and 0.002 respectively). CONCLUSIONS: This study demonstrated GA, foveal pit depth and the central foveal thickness could accurately predict the need for treatment with sensitivity, specificity, and diagnostic accuracy of 97%, 65% and 91.7% respectively. BioMed Central 2023-10-18 /pmc/articles/PMC10585878/ /pubmed/37853491 http://dx.doi.org/10.1186/s40942-023-00499-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Original Article Bazvand, Fatemeh Salari, Farhad Barzi, Navid Hasani Ghassemi, Fariba Maleki, Anahid Dastjani Farahani, Afsar Imani Fooladi, Marjan Taleghani, Naeeme Taslimi Shariati, Maryam Khoshnoud Harper, C. Armitage Mehrabi Bahar, Mohammadreza Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study |
title | Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study |
title_full | Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study |
title_fullStr | Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study |
title_full_unstemmed | Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study |
title_short | Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study |
title_sort | potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an oct-based study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585878/ https://www.ncbi.nlm.nih.gov/pubmed/37853491 http://dx.doi.org/10.1186/s40942-023-00499-0 |
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