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Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial
BACKGROUND: In rural African settings, most of the children under the coverage of Seasonal Malaria Chemoprevention (SMC) are also undernourished at the time of SMC delivery, justifying the need for packaging malarial and nutritional interventions. This study aimed at assessing the impact of SMC by c...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585892/ https://www.ncbi.nlm.nih.gov/pubmed/37853408 http://dx.doi.org/10.1186/s12936-023-04745-6 |
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author | Sondo, Paul Kaboré, Bérenger Rouamba, Toussaint Compaoré, Eulalie Tibiri, Yssimini Nadège Guillène Kaboré, Hyacinthe Abd-El Latif Faïçal Derra, Karim Tahita, Marc Christian Ilboudo, Hamidou Tougri, Gauthier Bouda, Ismaïla Dakyo, Tikanou Kafando, Hyacinthe Ouédraogo, Florence Rouamba, Eli Hien, So-vii Franck Kazienga, Adama Compaoré, Cheick Saïd Bambara, Estelle Nana, Macaire Dahal, Prabin Garanet, Franck Kaboré, William Léfèvre, Thierry Guerin, Philippe Tinto, Halidou |
author_facet | Sondo, Paul Kaboré, Bérenger Rouamba, Toussaint Compaoré, Eulalie Tibiri, Yssimini Nadège Guillène Kaboré, Hyacinthe Abd-El Latif Faïçal Derra, Karim Tahita, Marc Christian Ilboudo, Hamidou Tougri, Gauthier Bouda, Ismaïla Dakyo, Tikanou Kafando, Hyacinthe Ouédraogo, Florence Rouamba, Eli Hien, So-vii Franck Kazienga, Adama Compaoré, Cheick Saïd Bambara, Estelle Nana, Macaire Dahal, Prabin Garanet, Franck Kaboré, William Léfèvre, Thierry Guerin, Philippe Tinto, Halidou |
author_sort | Sondo, Paul |
collection | PubMed |
description | BACKGROUND: In rural African settings, most of the children under the coverage of Seasonal Malaria Chemoprevention (SMC) are also undernourished at the time of SMC delivery, justifying the need for packaging malarial and nutritional interventions. This study aimed at assessing the impact of SMC by coupling the intervention with nutrients supplementation for preventing malaria in children less than 5 years old in Burkina Faso. METHODS: A randomized trial was carried out between July 2020 and June 2021 in the health district of Nanoro, Burkina Faso. Children (n = 1059) under SMC coverage were randomly assigned to one of the three study arms SMC + Vitamin A (SMC-A, n = 353) or SMC + Vitamin A + Zinc (SMC-AZc, n = 353) or SMC + Vitamin A + PlumpyDoz(tm) (SMC-APd, n = 353)-a medium quantity—lipid-based nutrient supplement (MQ-LNS). Children were followed up for one year that included an active follow-up period of 6 months with scheduled monthly home visits followed by 6 months passive follow-up. At each visit, capillary blood sample was collected for malaria diagnosis by rapid diagnosis test (RDT). RESULTS: Adding nutritional supplements to SMC had an effect on the incidence of malaria. A reduction of 23% (adjusted IRR = 0.77 (95%CI 0.61–0.97) in the odds of having uncomplicated malaria in SMC-APd arm but not with SMC-AZc arm adjusted IRR = 0.82 (95%CI 0.65–1.04) compare to control arm was observed. A reduction of 52%, adjusted IRR = 0.48 (95%CI 0.23–0.98) in the odds of having severe malaria was observed in SMC-APd arm compared to control arm. Besides the effect on malaria, this combined strategy had an effect on all-cause morbidity. More specifically, a reduction of morbidity odds of 24%, adjusted IRR = 0.76 (95%CI 0.60–0.94) in SMC-APd arm compared to control arm was observed. Unlike clinical episodes, no effect of nutrient supplementation on cross sectional asymptomatic infections was observed. CONCLUSION: Adding nutritional supplements to SMC significantly increases the impact of this intervention for preventing children from malaria and other childhood infections. Trial registration: NCT04238845. |
format | Online Article Text |
id | pubmed-10585892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105858922023-10-20 Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial Sondo, Paul Kaboré, Bérenger Rouamba, Toussaint Compaoré, Eulalie Tibiri, Yssimini Nadège Guillène Kaboré, Hyacinthe Abd-El Latif Faïçal Derra, Karim Tahita, Marc Christian Ilboudo, Hamidou Tougri, Gauthier Bouda, Ismaïla Dakyo, Tikanou Kafando, Hyacinthe Ouédraogo, Florence Rouamba, Eli Hien, So-vii Franck Kazienga, Adama Compaoré, Cheick Saïd Bambara, Estelle Nana, Macaire Dahal, Prabin Garanet, Franck Kaboré, William Léfèvre, Thierry Guerin, Philippe Tinto, Halidou Malar J Research BACKGROUND: In rural African settings, most of the children under the coverage of Seasonal Malaria Chemoprevention (SMC) are also undernourished at the time of SMC delivery, justifying the need for packaging malarial and nutritional interventions. This study aimed at assessing the impact of SMC by coupling the intervention with nutrients supplementation for preventing malaria in children less than 5 years old in Burkina Faso. METHODS: A randomized trial was carried out between July 2020 and June 2021 in the health district of Nanoro, Burkina Faso. Children (n = 1059) under SMC coverage were randomly assigned to one of the three study arms SMC + Vitamin A (SMC-A, n = 353) or SMC + Vitamin A + Zinc (SMC-AZc, n = 353) or SMC + Vitamin A + PlumpyDoz(tm) (SMC-APd, n = 353)-a medium quantity—lipid-based nutrient supplement (MQ-LNS). Children were followed up for one year that included an active follow-up period of 6 months with scheduled monthly home visits followed by 6 months passive follow-up. At each visit, capillary blood sample was collected for malaria diagnosis by rapid diagnosis test (RDT). RESULTS: Adding nutritional supplements to SMC had an effect on the incidence of malaria. A reduction of 23% (adjusted IRR = 0.77 (95%CI 0.61–0.97) in the odds of having uncomplicated malaria in SMC-APd arm but not with SMC-AZc arm adjusted IRR = 0.82 (95%CI 0.65–1.04) compare to control arm was observed. A reduction of 52%, adjusted IRR = 0.48 (95%CI 0.23–0.98) in the odds of having severe malaria was observed in SMC-APd arm compared to control arm. Besides the effect on malaria, this combined strategy had an effect on all-cause morbidity. More specifically, a reduction of morbidity odds of 24%, adjusted IRR = 0.76 (95%CI 0.60–0.94) in SMC-APd arm compared to control arm was observed. Unlike clinical episodes, no effect of nutrient supplementation on cross sectional asymptomatic infections was observed. CONCLUSION: Adding nutritional supplements to SMC significantly increases the impact of this intervention for preventing children from malaria and other childhood infections. Trial registration: NCT04238845. BioMed Central 2023-10-18 /pmc/articles/PMC10585892/ /pubmed/37853408 http://dx.doi.org/10.1186/s12936-023-04745-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Sondo, Paul Kaboré, Bérenger Rouamba, Toussaint Compaoré, Eulalie Tibiri, Yssimini Nadège Guillène Kaboré, Hyacinthe Abd-El Latif Faïçal Derra, Karim Tahita, Marc Christian Ilboudo, Hamidou Tougri, Gauthier Bouda, Ismaïla Dakyo, Tikanou Kafando, Hyacinthe Ouédraogo, Florence Rouamba, Eli Hien, So-vii Franck Kazienga, Adama Compaoré, Cheick Saïd Bambara, Estelle Nana, Macaire Dahal, Prabin Garanet, Franck Kaboré, William Léfèvre, Thierry Guerin, Philippe Tinto, Halidou Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial |
title | Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial |
title_full | Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial |
title_fullStr | Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial |
title_full_unstemmed | Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial |
title_short | Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial |
title_sort | enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in burkina faso: a randomized open label trial |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585892/ https://www.ncbi.nlm.nih.gov/pubmed/37853408 http://dx.doi.org/10.1186/s12936-023-04745-6 |
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