Recent Advances of S–(18)F Radiochemistry for Positron Emission Tomography

[Image: see text] The click chemistry of sulfur(VI) fluoride exchange (SuFEx) has facilitated the widespread application of sulfur–fluoride compounds such as sulfonyl fluorides, fluorosulfates, and sulfamoyl fluorides in various fields, especially in the development of (18)F ligands for PET (positron emission tomography) imaging. In recent years, the prominent progress of sulfur–[(18)F]fluoride compounds has been achieved through the combination of (18)F and sulfur–fluoride chemistry. These compounds serve as potential (18)F tracers, (18)F synthons, and reagents for (18)F-fluorination, thereby complementing the range of (18)F ligands, typically C–(18)F structures, used in PET studies. This review aims to provide an overview of S–(18)F labeling reactions through examples of relevant (18)F compounds and highlight the advancements and breakthroughs achieved in the past decade.