A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, r...

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Detalles Bibliográficos
Autores principales: Rosas-Lemus, Monica, Dey, Supratim, Minasov, George, Tan, Kemin, Anderson, Spencer M., Brunzelle, Joseph, Nocadello, Salvatore, Shabalin, Ivan, Filippova, Ekaterina, Halavaty, Andrei, Kim, Youngchang, Maltseva, Natalia, Osipiuk, Jerzy, Minor, Wladek, Joachimiak, Andrzej, Savchenko, Alexei, Anderson, Wayne F., Satchell, Karla J. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Other Genetic Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586155/
https://www.ncbi.nlm.nih.gov/pubmed/37747257
http://dx.doi.org/10.1128/MRA.00507-23
Descripción
Sumario:Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

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