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A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile
Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, r...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586155/ https://www.ncbi.nlm.nih.gov/pubmed/37747257 http://dx.doi.org/10.1128/MRA.00507-23 |
| _version_ | 1785123098095255552 |
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| author | Rosas-Lemus, Monica Dey, Supratim Minasov, George Tan, Kemin Anderson, Spencer M. Brunzelle, Joseph Nocadello, Salvatore Shabalin, Ivan Filippova, Ekaterina Halavaty, Andrei Kim, Youngchang Maltseva, Natalia Osipiuk, Jerzy Minor, Wladek Joachimiak, Andrzej Savchenko, Alexei Anderson, Wayne F. Satchell, Karla J. F. |
| author_facet | Rosas-Lemus, Monica Dey, Supratim Minasov, George Tan, Kemin Anderson, Spencer M. Brunzelle, Joseph Nocadello, Salvatore Shabalin, Ivan Filippova, Ekaterina Halavaty, Andrei Kim, Youngchang Maltseva, Natalia Osipiuk, Jerzy Minor, Wladek Joachimiak, Andrzej Savchenko, Alexei Anderson, Wayne F. Satchell, Karla J. F. |
| author_sort | Rosas-Lemus, Monica |
| collection | PubMed |
| description | Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen. |
| format | Online Article Text |
| id | pubmed-10586155 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105861552023-10-20 A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile Rosas-Lemus, Monica Dey, Supratim Minasov, George Tan, Kemin Anderson, Spencer M. Brunzelle, Joseph Nocadello, Salvatore Shabalin, Ivan Filippova, Ekaterina Halavaty, Andrei Kim, Youngchang Maltseva, Natalia Osipiuk, Jerzy Minor, Wladek Joachimiak, Andrzej Savchenko, Alexei Anderson, Wayne F. Satchell, Karla J. F. Microbiol Resour Announc Other Genetic Resources Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen. American Society for Microbiology 2023-09-25 /pmc/articles/PMC10586155/ /pubmed/37747257 http://dx.doi.org/10.1128/MRA.00507-23 Text en Copyright © 2023 Rosas-Lemus et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Other Genetic Resources Rosas-Lemus, Monica Dey, Supratim Minasov, George Tan, Kemin Anderson, Spencer M. Brunzelle, Joseph Nocadello, Salvatore Shabalin, Ivan Filippova, Ekaterina Halavaty, Andrei Kim, Youngchang Maltseva, Natalia Osipiuk, Jerzy Minor, Wladek Joachimiak, Andrzej Savchenko, Alexei Anderson, Wayne F. Satchell, Karla J. F. A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile |
| title | A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile |
| title_full | A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile |
| title_fullStr | A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile |
| title_full_unstemmed | A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile |
| title_short | A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile |
| title_sort | high-throughput structural system biology approach to increase structure representation of proteins from clostridioides difficile |
| topic | Other Genetic Resources |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586155/ https://www.ncbi.nlm.nih.gov/pubmed/37747257 http://dx.doi.org/10.1128/MRA.00507-23 |
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