Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

Anti-TNF therapy can induce and maintain a remission status during intestinal bowel disease. However, up to 30% of patients do not respond to this therapy by mechanisms that are unknown. Here, we show that the absence of MCJ, a natural inhibitor of the respiratory chain Complex I, induces gut microb...

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Detalles Bibliográficos
Autores principales: Peña-Cearra, Ainize, Castelo, Janire, Lavín, Jose Luis, Gonzalez-Lopez, Monika, Pascual-Itoiz, Miguel Angel, Fuertes, Miguel, Gutiérrez de Juan, Virginia, Bárcena, Laura, Martín-Ruiz, Itziar, Pellón, Aize, Seoane, Iratxe, Barriales, Diego, Palacios, Ainhoa, Fullaondo, Asier, Rodríguez-Lago, Iago, Martinez-Chantar, María L., Aransay, Ana Mª, Rodriguez, Hector, Anguita, Juan, Abecia, Leticia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586225/
https://www.ncbi.nlm.nih.gov/pubmed/37842919
http://dx.doi.org/10.1080/19490976.2023.2266626

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