Cargando…

Design and Synthesis of Ketenimine Sulfonamide Conjugates through Multicomponent Reactions; A Combined Cytotoxic Analysis and Computational Exploration

[Image: see text] Multicomponent reactions involving zwitterion generated from dimethyl acetylenedicarboxylate, aryl sulfonamide, and isocyanide to generate sulfonamide-conjugated ketenimines is reported. The synthetic strategy adopted is highly atom economical and stereoselective. Ketenimine sulfon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prabhu, Deepak J., Ray, Ujjayinee, Rajeev, Anjaly, Joy, Reshma, George, Abi Thoppilan, George, Jinu, Raghavan, Sathees C., John, Franklin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586297/ https://www.ncbi.nlm.nih.gov/pubmed/37867708 http://dx.doi.org/10.1021/acsomega.3c05816

Ejemplares similares

High-Level Rovibrational Calculations on Ketenimine
por: Tschöpe, Martin, et al.
Publicado: (2021)

Block Copolymer Encapsulation of Disarib, an Inhibitor of BCL2 for Improved Chemotherapeutic Potential
por: Joy, Reshma, et al.
Publicado: (2023)

Synthesis of Highly Reactive Ketenimines via Photochemical Rearrangement of Isoxazoles
por: Bracken, Cormac, et al.
Publicado: (2023)

Copper-catalyzed Z-selective synthesis of acrylamides and polyacrylamides via alkylidene ketenimines
por: Duan, Xuelun, et al.
Publicado: (2022)

A Lewis Acid Stabilized Ketenimine in an Unusual Variant of the Electrophilic Aromatic Substitution
por: Surkau, Jonas, et al.
Publicado: (2022)

Acute toxicity analysis of an inhibitor of BCL2, Disarib, in rats
por: Sharma, Shivangi, et al.
Publicado: (2021)

Blue Light-Promoted Cross-Coupling of α-Diazo Esters with Isocyanides: Synthesis of Ester-Functionalized Ketenimines
por: Sakharov, Pavel A., et al.
Publicado: (2022)

Methyl Angolensate from Callus of Indian Redwood Induces Cytotoxicity in Human Breast Cancer Cells
por: Chiruvella, Kishore K., et al.
Publicado: (2010)

Access to New Cytotoxic Triterpene and Steroidal Acid-TEMPO Conjugates by Ugi Multicomponent-Reactions †
por: Sultani, Haider N., et al.
Publicado: (2021)

Tandem Cu-catalyzed ketenimine formation and intramolecular nucleophile capture: Synthesis of 1,2-dihydro-2-iminoquinolines from 1-(o-acetamidophenyl)propargyl alcohols
por: Kumar, Gadi Ranjith, et al.
Publicado: (2014)

Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides
por: Hwang, Yu Jin, et al.
Publicado: (2013)

Designing Cascades of Electron Transfer Processes in Multicomponent Graphene Conjugates
por: Limosani, Francesca, et al.
Publicado: (2020)

Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-Azabicycloalkane Skeleton
por: Samadaei, Mahzeiar, et al.
Publicado: (2020)

Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids
por: Aboukhatwa, Shaimaa M., et al.
Publicado: (2023)

Efficient Multicomponent Synthesis of Diverse Antibacterial Embelin-Privileged Structure Conjugates
por: Martín-Acosta, Pedro, et al.
Publicado: (2020)

Cyanovinylation of Aldehydes: Organocatalytic Multicomponent Synthesis of Conjugated Cyanomethyl Vinyl Ethers
por: Delgado-Hernández, Samuel, et al.
Publicado: (2021)

In Vitro Production of Echioidinin, 7-O-Methywogonin from Callus Cultures of Andrographis lineata and Their Cytotoxicity on Cancer Cells
por: Mohammed, Arifullah, et al.
Publicado: (2015)

Folic acid-sulfonamide conjugates as antibacterial agents: design, synthesis and molecular docking studies
por: Shahzad, Shabnam, et al.
Publicado: (2020)

Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues
por: Purder, Patrick L., et al.
Publicado: (2023)

How does DNA break during chromosomal translocations?
por: Nambiar, Mridula, et al.
Publicado: (2011)

Nonhomologous DNA End Joining in Cell-Free Extracts
por: Sharma, Sheetal, et al.
Publicado: (2010)

Biochemical Characterization of Nonamer Binding Domain of RAG1 Reveals its Thymine Preference with Respect to Length and Position
por: Raveendran, Deepthi, et al.
Publicado: (2016)

Click Chemistry and Multicomponent Reaction for Linker Diversification of Zinc Dipicolylamine-Based Drug Conjugates
por: Tsai, Ching-Hua, et al.
Publicado: (2022)

Targeting COVID-19 pandemic: in silico evaluation of 2-hydroxy-1, 2-diphenylethanone N(4)-methyl-N(4)-phenylthiosemicarbazone as a potential inhibitor of SARS-CoV-2
por: Jeevana, Rajan, et al.
Publicado: (2022)

Sulfonamide Allergies
por: Giles, Amber, et al.
Publicado: (2019)

Synthesis and cytotoxic activities of novel copper and silver complexes of 1,3-diaryltriazene-substituted sulfonamides
por: Canakci, Dilek, et al.
Publicado: (2018)

Optimization and Comparison of Synthetic Procedures for a Group of Triazinyl-Substituted Benzene-Sulfonamide Conjugates with Amino Acids
por: Krajčiová, Dominika, et al.
Publicado: (2017)

GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner
por: Das, Kohal, et al.
Publicado: (2016)

SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining
por: Manjunath, Meghana, et al.
Publicado: (2021)

A palladium-catalysed multicomponent coupling approach to conjugated poly(1,3-dipoles) and polyheterocycles
por: Leitch, David C., et al.
Publicado: (2015)

relA Inactivation Converts Sulfonamides Into Bactericidal Compounds
por: Si, Lizhen, et al.
Publicado: (2021)

Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells
por: Lee, Seul Ki Chan, et al.
Publicado: (2011)

Synthesis and Cytotoxic Evaluation of Some Novel SulfonamideDerivativesAgainst a Few Human Cancer Cells
por: Mirian, Mina, et al.
Publicado: (2011)

Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents
por: Aljohani, Faizah S., et al.
Publicado: (2022)

Quinoline-2-sulfonamide
por: Marciniec, Krzysztof, et al.
Publicado: (2013)

Quinoline-8-sulfonamide
por: Marciniec, Krzysztof, et al.
Publicado: (2012)

Special Issue: Sulfonamides
por: Supuran, Claudiu T.
Publicado: (2017)

Multicomponent reactions
por: Müller, Thomas J J
Publicado: (2011)

Multicomponent Reactions
por: Cimarelli, Cristina
Publicado: (2019)

Effectiveness of Multicomponent Intervention on Quality of Life of Family Caregivers of Cancer Patients
por: Nayak, Malathi G, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_319qno7aso4ornmk3jlv74v1ms