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Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia

Developmental dyscalculia is a neurodevelopmental disorder specific to arithmetic learning even with normal intelligence and age-appropriate education. Difficulties often persist from childhood through adulthood lowering the individual’s quality of life. However, the neural correlates of development...

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Autores principales: Ayyıldız, Nazife, Beyer, Frauke, Üstün, Sertaç, Kale, Emre H., Mançe Çalışır, Öykü, Uran, Pınar, Öner, Özgür, Olkun, Sinan, Anwander, Alfred, Witte, A. Veronica, Villringer, Arno, Çiçek, Metehan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586317/
https://www.ncbi.nlm.nih.gov/pubmed/37868699
http://dx.doi.org/10.3389/fnhum.2023.1147352
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author Ayyıldız, Nazife
Beyer, Frauke
Üstün, Sertaç
Kale, Emre H.
Mançe Çalışır, Öykü
Uran, Pınar
Öner, Özgür
Olkun, Sinan
Anwander, Alfred
Witte, A. Veronica
Villringer, Arno
Çiçek, Metehan
author_facet Ayyıldız, Nazife
Beyer, Frauke
Üstün, Sertaç
Kale, Emre H.
Mançe Çalışır, Öykü
Uran, Pınar
Öner, Özgür
Olkun, Sinan
Anwander, Alfred
Witte, A. Veronica
Villringer, Arno
Çiçek, Metehan
author_sort Ayyıldız, Nazife
collection PubMed
description Developmental dyscalculia is a neurodevelopmental disorder specific to arithmetic learning even with normal intelligence and age-appropriate education. Difficulties often persist from childhood through adulthood lowering the individual’s quality of life. However, the neural correlates of developmental dyscalculia are poorly understood. This study aimed to identify brain structural connectivity alterations in developmental dyscalculia. All participants were recruited from a large scale, non-referred population sample in a longitudinal design. We studied 10 children with developmental dyscalculia (11.3 ± 0.7 years) and 16 typically developing peers (11.2 ± 0.6 years) using diffusion-weighted magnetic resonance imaging. We assessed white matter microstructure with tract-based spatial statistics in regions-of-interest tracts that had previously been related to math ability in children. Then we used global probabilistic tractography for the first time to measure and compare tract length between developmental dyscalculia and typically developing groups. The high angular resolution diffusion-weighted magnetic resonance imaging and crossing-fiber probabilistic tractography allowed us to evaluate the length of the pathways compared to previous studies. The major findings of our study were reduced white matter coherence and shorter tract length of the left superior longitudinal/arcuate fasciculus and left anterior thalamic radiation in the developmental dyscalculia group. Furthermore, the lower white matter coherence and shorter pathways tended to be associated with the lower math performance. These results from the regional analyses indicate that learning, memory and language-related pathways in the left hemisphere might be related to developmental dyscalculia in children.
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spelling pubmed-105863172023-10-20 Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia Ayyıldız, Nazife Beyer, Frauke Üstün, Sertaç Kale, Emre H. Mançe Çalışır, Öykü Uran, Pınar Öner, Özgür Olkun, Sinan Anwander, Alfred Witte, A. Veronica Villringer, Arno Çiçek, Metehan Front Hum Neurosci Human Neuroscience Developmental dyscalculia is a neurodevelopmental disorder specific to arithmetic learning even with normal intelligence and age-appropriate education. Difficulties often persist from childhood through adulthood lowering the individual’s quality of life. However, the neural correlates of developmental dyscalculia are poorly understood. This study aimed to identify brain structural connectivity alterations in developmental dyscalculia. All participants were recruited from a large scale, non-referred population sample in a longitudinal design. We studied 10 children with developmental dyscalculia (11.3 ± 0.7 years) and 16 typically developing peers (11.2 ± 0.6 years) using diffusion-weighted magnetic resonance imaging. We assessed white matter microstructure with tract-based spatial statistics in regions-of-interest tracts that had previously been related to math ability in children. Then we used global probabilistic tractography for the first time to measure and compare tract length between developmental dyscalculia and typically developing groups. The high angular resolution diffusion-weighted magnetic resonance imaging and crossing-fiber probabilistic tractography allowed us to evaluate the length of the pathways compared to previous studies. The major findings of our study were reduced white matter coherence and shorter tract length of the left superior longitudinal/arcuate fasciculus and left anterior thalamic radiation in the developmental dyscalculia group. Furthermore, the lower white matter coherence and shorter pathways tended to be associated with the lower math performance. These results from the regional analyses indicate that learning, memory and language-related pathways in the left hemisphere might be related to developmental dyscalculia in children. Frontiers Media S.A. 2023-09-28 /pmc/articles/PMC10586317/ /pubmed/37868699 http://dx.doi.org/10.3389/fnhum.2023.1147352 Text en Copyright © 2023 Ayyıldız, Beyer, Üstün, Kale, Mançe Çalışır, Uran, Öner, Olkun, Anwander, Witte, Villringer and Çiçek. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Ayyıldız, Nazife
Beyer, Frauke
Üstün, Sertaç
Kale, Emre H.
Mançe Çalışır, Öykü
Uran, Pınar
Öner, Özgür
Olkun, Sinan
Anwander, Alfred
Witte, A. Veronica
Villringer, Arno
Çiçek, Metehan
Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
title Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
title_full Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
title_fullStr Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
title_full_unstemmed Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
title_short Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
title_sort changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586317/
https://www.ncbi.nlm.nih.gov/pubmed/37868699
http://dx.doi.org/10.3389/fnhum.2023.1147352
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