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Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases
OBJECTIVE: The pathogenesis of peptic ulcer diseases (PUDs) involves multiple factors, and the contribution of gut microbiota to this process remains unclear. While previous studies have associated gut microbiota with peptic ulcers, the precise nature of the relationship, whether causal or influence...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586326/ https://www.ncbi.nlm.nih.gov/pubmed/37869000 http://dx.doi.org/10.3389/fimmu.2023.1260780 |
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author | Zhao, Jingwei Hou, Yucheng Xie, Tianyi Zhu, Yizhang Feng, Xinyi Zhang, Yong Yang, Ziyi Gong, Wei |
author_facet | Zhao, Jingwei Hou, Yucheng Xie, Tianyi Zhu, Yizhang Feng, Xinyi Zhang, Yong Yang, Ziyi Gong, Wei |
author_sort | Zhao, Jingwei |
collection | PubMed |
description | OBJECTIVE: The pathogenesis of peptic ulcer diseases (PUDs) involves multiple factors, and the contribution of gut microbiota to this process remains unclear. While previous studies have associated gut microbiota with peptic ulcers, the precise nature of the relationship, whether causal or influenced by biases, requires further elucidation. DESIGN: The largest meta-analysis of genome-wide association studies was conducted by the MiBioGen consortium, which provided the summary statistics of gut microbiota for implementation in the Mendelian randomization (MR) analysis. Summary statistics for five types of PUDs were compiled using the FinnGen Consortium R8 release data. Various statistical techniques, including inverse variance weighting (IVW), MR-Egger, weighted median (WM), weighted mode, and simple mode, were employed to assess the causal relationships between gut microbiota and these five PUDs. RESULT: In the intestinal microbiome of 119 known genera, we found a total of 14 causal associations with various locations of PUDs and reported the potential pathogenic bacteria of Bilophila et al. Among them, four had causal relationships with esophageal ulcer, one with gastric ulcer, three with gastroduodenal ulcer, four with duodenal ulcer, and two with gastrojejunal ulcer. CONCLUSION: In this study, the pathogenic bacterial genera in the gut microbiota that promote the occurrence of PUDs were found to be causally related. There are multiple correlations between intestinal flora and PUDs, overlapping PUDs have overlapping associated genera. The variance in ulcer-related bacterial genera across different locations underscores the potential influence of anatomical locations and physiological functions. |
format | Online Article Text |
id | pubmed-10586326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105863262023-10-20 Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases Zhao, Jingwei Hou, Yucheng Xie, Tianyi Zhu, Yizhang Feng, Xinyi Zhang, Yong Yang, Ziyi Gong, Wei Front Immunol Immunology OBJECTIVE: The pathogenesis of peptic ulcer diseases (PUDs) involves multiple factors, and the contribution of gut microbiota to this process remains unclear. While previous studies have associated gut microbiota with peptic ulcers, the precise nature of the relationship, whether causal or influenced by biases, requires further elucidation. DESIGN: The largest meta-analysis of genome-wide association studies was conducted by the MiBioGen consortium, which provided the summary statistics of gut microbiota for implementation in the Mendelian randomization (MR) analysis. Summary statistics for five types of PUDs were compiled using the FinnGen Consortium R8 release data. Various statistical techniques, including inverse variance weighting (IVW), MR-Egger, weighted median (WM), weighted mode, and simple mode, were employed to assess the causal relationships between gut microbiota and these five PUDs. RESULT: In the intestinal microbiome of 119 known genera, we found a total of 14 causal associations with various locations of PUDs and reported the potential pathogenic bacteria of Bilophila et al. Among them, four had causal relationships with esophageal ulcer, one with gastric ulcer, three with gastroduodenal ulcer, four with duodenal ulcer, and two with gastrojejunal ulcer. CONCLUSION: In this study, the pathogenic bacterial genera in the gut microbiota that promote the occurrence of PUDs were found to be causally related. There are multiple correlations between intestinal flora and PUDs, overlapping PUDs have overlapping associated genera. The variance in ulcer-related bacterial genera across different locations underscores the potential influence of anatomical locations and physiological functions. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10586326/ /pubmed/37869000 http://dx.doi.org/10.3389/fimmu.2023.1260780 Text en Copyright © 2023 Zhao, Hou, Xie, Zhu, Feng, Zhang, Yang and Gong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhao, Jingwei Hou, Yucheng Xie, Tianyi Zhu, Yizhang Feng, Xinyi Zhang, Yong Yang, Ziyi Gong, Wei Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases |
title | Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases |
title_full | Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases |
title_fullStr | Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases |
title_full_unstemmed | Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases |
title_short | Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases |
title_sort | genome-wide mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586326/ https://www.ncbi.nlm.nih.gov/pubmed/37869000 http://dx.doi.org/10.3389/fimmu.2023.1260780 |
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