In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using (11)C-CHDI-180R PET in a Nonhuman Primate Model of Huntington Disease

Huntington disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine (CAG) trinucleotide expansion in the huntingtin (HTT) gene that encodes the mutant huntingtin protein (mHTT). Visualization and quantification of cerebral mHTT will provide a proxy for target engagement and a...

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Detalles Bibliográficos
Autores principales: Bertoglio, Daniele, Weiss, Alison R., Liguore, William, Martin, Lauren Drew, Hobbs, Theodore, Templon, John, Srinivasan, Sathya, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Khetarpal, Vinod, Verhaeghe, Jeroen, Staelens, Steven, Link, Jeanne, Liu, Longbin, Bard, Jonathan A., McBride, Jodi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Nuclear Medicine 2023
Materias:
Basic Science Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586486/
https://www.ncbi.nlm.nih.gov/pubmed/37591545
http://dx.doi.org/10.2967/jnumed.123.265569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586486/
https://www.ncbi.nlm.nih.gov/pubmed/37591545
http://dx.doi.org/10.2967/jnumed.123.265569

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