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Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease
Calciphylaxis, or calcific uremic arteriolopathy, is a rare and deadly disease that affects patients with end-stage renal disease (ESRD). It typically manifests in the abdomen and lower extremities. We present a case of a 59-year-old female patient on dialysis due to ESRD who complained of a three-w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586526/ https://www.ncbi.nlm.nih.gov/pubmed/37868583 http://dx.doi.org/10.7759/cureus.45557 |
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author | Khudair, Ahmed D Khudair, Aiman D Awadh, Mohamed Pérez Romano, Nuria S Darwish, Abdulla |
author_facet | Khudair, Ahmed D Khudair, Aiman D Awadh, Mohamed Pérez Romano, Nuria S Darwish, Abdulla |
author_sort | Khudair, Ahmed D |
collection | PubMed |
description | Calciphylaxis, or calcific uremic arteriolopathy, is a rare and deadly disease that affects patients with end-stage renal disease (ESRD). It typically manifests in the abdomen and lower extremities. We present a case of a 59-year-old female patient on dialysis due to ESRD who complained of a three-week history of hemorrhagic and painful bilateral lower limb lesions. The predominant clinical suspicion was warfarin-induced skin necrosis (WISN); however, the persistence of unresolved skin lesions post-warfarin cessation generated the impression of calciphylaxis. A skin biopsy confirmed the classical histological findings associated with calciphylaxis. This paper highlights the possible importance of warfarin being an inciting event, as well as the early differentiation between the presentations of WISN and calciphylaxis. |
format | Online Article Text |
id | pubmed-10586526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-105865262023-10-20 Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease Khudair, Ahmed D Khudair, Aiman D Awadh, Mohamed Pérez Romano, Nuria S Darwish, Abdulla Cureus Pathology Calciphylaxis, or calcific uremic arteriolopathy, is a rare and deadly disease that affects patients with end-stage renal disease (ESRD). It typically manifests in the abdomen and lower extremities. We present a case of a 59-year-old female patient on dialysis due to ESRD who complained of a three-week history of hemorrhagic and painful bilateral lower limb lesions. The predominant clinical suspicion was warfarin-induced skin necrosis (WISN); however, the persistence of unresolved skin lesions post-warfarin cessation generated the impression of calciphylaxis. A skin biopsy confirmed the classical histological findings associated with calciphylaxis. This paper highlights the possible importance of warfarin being an inciting event, as well as the early differentiation between the presentations of WISN and calciphylaxis. Cureus 2023-09-19 /pmc/articles/PMC10586526/ /pubmed/37868583 http://dx.doi.org/10.7759/cureus.45557 Text en Copyright © 2023, Khudair et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Khudair, Ahmed D Khudair, Aiman D Awadh, Mohamed Pérez Romano, Nuria S Darwish, Abdulla Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease |
title | Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease |
title_full | Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease |
title_fullStr | Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease |
title_full_unstemmed | Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease |
title_short | Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease |
title_sort | calciphylaxis: a rare complication with a fatal outcome in end-stage renal disease |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586526/ https://www.ncbi.nlm.nih.gov/pubmed/37868583 http://dx.doi.org/10.7759/cureus.45557 |
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