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Tools and techniques to identify, study, and control Candida auris
Candida auris, is an emerging fungal pathogen that can cause life-threatening infections in humans. Unlike many other Candida species that colonize the intestine, C. auris most efficiently colonizes the skin. Such colonization contaminates the patient’s environment and can result in rapid nosocomial...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586630/ https://www.ncbi.nlm.nih.gov/pubmed/37856418 http://dx.doi.org/10.1371/journal.ppat.1011698 |
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author | Carty, James Chowdhary, Anuradha Bernstein, Douglas Thangamani, Shankar |
author_facet | Carty, James Chowdhary, Anuradha Bernstein, Douglas Thangamani, Shankar |
author_sort | Carty, James |
collection | PubMed |
description | Candida auris, is an emerging fungal pathogen that can cause life-threatening infections in humans. Unlike many other Candida species that colonize the intestine, C. auris most efficiently colonizes the skin. Such colonization contaminates the patient’s environment and can result in rapid nosocomial transmission. In addition, this transmission can lead to outbreaks of systemic infections that have mortality rates between 40% and 60%. C. auris isolates resistant to all known classes of antifungals have been identified and as such, understanding the underlying biochemical mechanisms of how skin colonization initiates and progresses is critical to developing better therapeutic options. With this review, we briefly summarize what is known about horizontal transmission and current tools used to identify, understand, and control C. auris infections. |
format | Online Article Text |
id | pubmed-10586630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105866302023-10-20 Tools and techniques to identify, study, and control Candida auris Carty, James Chowdhary, Anuradha Bernstein, Douglas Thangamani, Shankar PLoS Pathog Pearls Candida auris, is an emerging fungal pathogen that can cause life-threatening infections in humans. Unlike many other Candida species that colonize the intestine, C. auris most efficiently colonizes the skin. Such colonization contaminates the patient’s environment and can result in rapid nosocomial transmission. In addition, this transmission can lead to outbreaks of systemic infections that have mortality rates between 40% and 60%. C. auris isolates resistant to all known classes of antifungals have been identified and as such, understanding the underlying biochemical mechanisms of how skin colonization initiates and progresses is critical to developing better therapeutic options. With this review, we briefly summarize what is known about horizontal transmission and current tools used to identify, understand, and control C. auris infections. Public Library of Science 2023-10-19 /pmc/articles/PMC10586630/ /pubmed/37856418 http://dx.doi.org/10.1371/journal.ppat.1011698 Text en © 2023 Carty et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pearls Carty, James Chowdhary, Anuradha Bernstein, Douglas Thangamani, Shankar Tools and techniques to identify, study, and control Candida auris |
title | Tools and techniques to identify, study, and control Candida auris |
title_full | Tools and techniques to identify, study, and control Candida auris |
title_fullStr | Tools and techniques to identify, study, and control Candida auris |
title_full_unstemmed | Tools and techniques to identify, study, and control Candida auris |
title_short | Tools and techniques to identify, study, and control Candida auris |
title_sort | tools and techniques to identify, study, and control candida auris |
topic | Pearls |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586630/ https://www.ncbi.nlm.nih.gov/pubmed/37856418 http://dx.doi.org/10.1371/journal.ppat.1011698 |
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