Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling

Tissue development entails genetically programmed differentiation of immature cell types to mature, fully differentiated cells. Exposure during development to non-mutagenic environmental factors can contribute to cancer risk, but the underlying mechanisms are not understood. We used a mouse model of...

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Detalles Bibliográficos
Autores principales: Padilla-Banks, Elizabeth, Jefferson, Wendy N., Papas, Brian N., Suen, Alisa A., Xu, Xin, Carreon, Diana V., Willson, Cynthia J., Quist, Erin M., Williams, Carmen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586657/
https://www.ncbi.nlm.nih.gov/pubmed/37856394
http://dx.doi.org/10.1371/journal.pbio.3002334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586657/
https://www.ncbi.nlm.nih.gov/pubmed/37856394
http://dx.doi.org/10.1371/journal.pbio.3002334

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