Cargando…

Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling

Tissue development entails genetically programmed differentiation of immature cell types to mature, fully differentiated cells. Exposure during development to non-mutagenic environmental factors can contribute to cancer risk, but the underlying mechanisms are not understood. We used a mouse model of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Padilla-Banks, Elizabeth, Jefferson, Wendy N., Papas, Brian N., Suen, Alisa A., Xu, Xin, Carreon, Diana V., Willson, Cynthia J., Quist, Erin M., Williams, Carmen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586657/ https://www.ncbi.nlm.nih.gov/pubmed/37856394 http://dx.doi.org/10.1371/journal.pbio.3002334

Ejemplares similares

Widespread enhancer activation via ERα mediates estrogen response in vivo during uterine development
por: Jefferson, Wendy N, et al.
Publicado: (2018)

Uterine Patterning, Endometrial Gland Development, and Implantation Failure in Mice Exposed Neonatally to Genistein
por: Jefferson, Wendy N., et al.
Publicado: (2020)

Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/β-Catenin Signaling Pathways
por: Mandal, Animesh, et al.
Publicado: (2015)

The immature mouse is a suitable model for detection of estrogenicity in the uterotropic bioassay.
por: Padilla-Banks, E, et al.
Publicado: (2001)

Estrogen Receptor 1 Inhibition of Wnt/β-Catenin Signaling Contributes to Sex Differences in Hepatocarcinogenesis
por: Bhat, Mamatha, et al.
Publicado: (2021)

Cyclin G2 Suppresses Estrogen-Mediated Osteogenesis through Inhibition of Wnt/β-Catenin Signaling
por: Gao, Jinlan, et al.
Publicado: (2014)

Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signaling
por: Bernaudo, S, et al.
Publicado: (2016)

Avasimibe Alleviates Disruption of the Airway Epithelial Barrier by Suppressing the Wnt/β-Catenin Signaling Pathway
por: Zhou, Zicong, et al.
Publicado: (2022)

Estrogen Receptors and Estrogen-Induced Uterine Vasodilation in Pregnancy
por: Bai, Jin, et al.
Publicado: (2020)

Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells
por: Xiang, Tingxiu, et al.
Publicado: (2013)

Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway
por: Liang, Junrong, et al.
Publicado: (2022)

Erratum: Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signalling
por: Bernaudo, S, et al.
Publicado: (2016)

Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer
por: Abreu de Oliveira, Willy Antoni, et al.
Publicado: (2021)

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin
por: Aznar, Nicolas, et al.
Publicado: (2017)

Crosstalk between Wnt/β-Catenin and Estrogen Receptor Signaling Synergistically Promotes Osteogenic Differentiation of Mesenchymal Progenitor Cells
por: Gao, Yanhong, et al.
Publicado: (2013)

EFEMP1 is repressed by estrogen and inhibits the epithelial-mesenchymal transition via Wnt/β-catenin signaling in endometrial carcinoma
por: Yang, Tingting, et al.
Publicado: (2016)

Estrogen attenuates TGF-β1-induced EMT in intrauterine adhesion by activating Wnt/β-catenin signaling pathway
por: Cao, Jia, et al.
Publicado: (2020)

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling
por: Geng, Ajun, et al.
Publicado: (2020)

Heparanase-Induced Activation of AKT Stabilizes β-Catenin and Modulates Wnt/β-Catenin Signaling during Herpes Simplex Virus 1 Infection
por: Koujah, Lulia, et al.
Publicado: (2021)

WNT/β-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma
por: Zhu, Liang, et al.
Publicado: (2020)

Disruption of Wnt/β-catenin Signaling in Odontoblasts and Cementoblasts Arrests Tooth Root Development in Postnatal Mouse Teeth
por: Zhang, Ran, et al.
Publicado: (2013)

Targeting Oncogenic Wnt/β-Catenin Signaling in Adrenocortical Carcinoma Disrupts ECM Expression and Impairs Tumor Growth
por: Penny, Morgan K., et al.
Publicado: (2023)

Estrogen Receptor 1 (ESR1) and the Wnt/β-Catenin Pathway Mediate the Effect of the Coumarin Derivative Umbelliferon on Bone Mineralization
por: Pelusi, Letizia, et al.
Publicado: (2022)

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus
por: Orellana, Ana Maria Marques, et al.
Publicado: (2015)

CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer
por: Zheng, Chao-Hui, et al.
Publicado: (2018)

Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways
por: Huang, Yanran, et al.
Publicado: (2020)

Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?
por: Prossomariti, Anna, et al.
Publicado: (2020)

WNKs in Wnt/β-catenin signaling
por: Serysheva, Ekatherina, et al.
Publicado: (2014)

Wnt/β-Catenin Signaling and Obesity
por: Chen, Na, et al.
Publicado: (2018)

LncRNA APTR Promotes Uterine Leiomyoma Cell Proliferation by Targeting ERα to Activate the Wnt/β-Catenin Pathway
por: Zhou, Weiqiang, et al.
Publicado: (2021)

Antagonism of Cell Adhesion by an α-Catenin Mutant, and of the Wnt-signaling Pathway by α-Catenin in Xenopus Embryos
por: Sehgal, Ravinder N.M., et al.
Publicado: (1997)

Effects of Estrogens and Estrogenic Disrupting Compounds on Fish Mineralized Tissues
por: Pinto, Patricia I. S., et al.
Publicado: (2014)

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
por: Jung, Youn-Sang, et al.
Publicado: (2015)

Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling
por: Janda, Claudia Y., et al.
Publicado: (2017)

Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis
por: de Winter, Twan J. J., et al.
Publicado: (2021)

Estrogen-Induced Uterine Vasodilation in Pregnancy and Preeclampsia
por: Li, Yan, et al.
Publicado: (2021)

Haemophilus parasuis Infection Disrupts Adherens Junctions and Initializes EMT Dependent on Canonical Wnt/β-Catenin Signaling Pathway
por: Hua, Kexin, et al.
Publicado: (2018)

Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating Wnt/Beta-Catenin Signaling
por: Xu, Wei, et al.
Publicado: (2020)

Epigenetic deregulation of MLF1 drives intrahepatic cholangiocarcinoma progression through EGFR/AKT and Wnt/β-catenin signaling
por: Tang, Zengwei, et al.
Publicado: (2023)

5-aza-2′-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas
por: Carbajo-García, María Cristina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1madm2o341r9jqpdqdh20gecio