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Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar plaque growth within the brain is unclear. Here w...

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Detalles Bibliográficos
Autores principales:	Aguilar-Calvo, Patricia, Malik, Adela, Sandoval, Daniel R., Barback, Christopher, Orrù, Christina D., Standke, Heidi G., Thomas, Olivia R., Dwyer, Chrissa A., Pizzo, Donald P., Bapat, Jaidev, Soldau, Katrin, Ogawa, Ryotaro, Riley, Mckenzie B., Nilsson, K. Peter R., Kraus, Allison, Caughey, Byron, Iliff, Jeffrey J., Vera, David R., Esko, Jeffrey D., Sigurdson, Christina J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586673/ https://www.ncbi.nlm.nih.gov/pubmed/37747931 http://dx.doi.org/10.1371/journal.ppat.1011487

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