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Chemical biology tools for protein labelling: insights into cell–cell communication
Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Portland Press Ltd.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586760/ https://www.ncbi.nlm.nih.gov/pubmed/37732646 http://dx.doi.org/10.1042/BCJ20220309 |
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author | Wright, Megan H. |
author_facet | Wright, Megan H. |
author_sort | Wright, Megan H. |
collection | PubMed |
description | Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell–cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out of protein activity or interactions in downstream signalling pathways, or discover protein–protein interactions across cell–cell interfaces. |
format | Online Article Text |
id | pubmed-10586760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105867602023-10-20 Chemical biology tools for protein labelling: insights into cell–cell communication Wright, Megan H. Biochem J Chemical Biology Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell–cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out of protein activity or interactions in downstream signalling pathways, or discover protein–protein interactions across cell–cell interfaces. Portland Press Ltd. 2023-09-21 /pmc/articles/PMC10586760/ /pubmed/37732646 http://dx.doi.org/10.1042/BCJ20220309 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of Leeds in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. |
spellingShingle | Chemical Biology Wright, Megan H. Chemical biology tools for protein labelling: insights into cell–cell communication |
title | Chemical biology tools for protein labelling: insights into cell–cell communication |
title_full | Chemical biology tools for protein labelling: insights into cell–cell communication |
title_fullStr | Chemical biology tools for protein labelling: insights into cell–cell communication |
title_full_unstemmed | Chemical biology tools for protein labelling: insights into cell–cell communication |
title_short | Chemical biology tools for protein labelling: insights into cell–cell communication |
title_sort | chemical biology tools for protein labelling: insights into cell–cell communication |
topic | Chemical Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586760/ https://www.ncbi.nlm.nih.gov/pubmed/37732646 http://dx.doi.org/10.1042/BCJ20220309 |
work_keys_str_mv | AT wrightmeganh chemicalbiologytoolsforproteinlabellinginsightsintocellcellcommunication |