Cargando…

Chemical biology tools for protein labelling: insights into cell–cell communication

Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering a...

Descripción completa

Detalles Bibliográficos
Autor principal: Wright, Megan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586760/
https://www.ncbi.nlm.nih.gov/pubmed/37732646
http://dx.doi.org/10.1042/BCJ20220309
_version_ 1785123211864702976
author Wright, Megan H.
author_facet Wright, Megan H.
author_sort Wright, Megan H.
collection PubMed
description Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell–cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out of protein activity or interactions in downstream signalling pathways, or discover protein–protein interactions across cell–cell interfaces.
format Online
Article
Text
id pubmed-10586760
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-105867602023-10-20 Chemical biology tools for protein labelling: insights into cell–cell communication Wright, Megan H. Biochem J Chemical Biology Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell–cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out of protein activity or interactions in downstream signalling pathways, or discover protein–protein interactions across cell–cell interfaces. Portland Press Ltd. 2023-09-21 /pmc/articles/PMC10586760/ /pubmed/37732646 http://dx.doi.org/10.1042/BCJ20220309 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of Leeds in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Chemical Biology
Wright, Megan H.
Chemical biology tools for protein labelling: insights into cell–cell communication
title Chemical biology tools for protein labelling: insights into cell–cell communication
title_full Chemical biology tools for protein labelling: insights into cell–cell communication
title_fullStr Chemical biology tools for protein labelling: insights into cell–cell communication
title_full_unstemmed Chemical biology tools for protein labelling: insights into cell–cell communication
title_short Chemical biology tools for protein labelling: insights into cell–cell communication
title_sort chemical biology tools for protein labelling: insights into cell–cell communication
topic Chemical Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586760/
https://www.ncbi.nlm.nih.gov/pubmed/37732646
http://dx.doi.org/10.1042/BCJ20220309
work_keys_str_mv AT wrightmeganh chemicalbiologytoolsforproteinlabellinginsightsintocellcellcommunication