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Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

Conventional protein kinase C (cPKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations identified in neurodegeneration. PKC with impaired autoinhibition is removed from the cell by quality-control mecha...

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Detalles Bibliográficos
Autores principales:	Jones, Alexander C., Kornev, Alexandr P., Weng, Jui-Hung, Manning, Gerard, Taylor, Susan S., Newton, Alexandra C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Molecular Bases of Health & Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586763/ https://www.ncbi.nlm.nih.gov/pubmed/37551632 http://dx.doi.org/10.1042/BCJ20220397

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