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Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort
In recent years, organophosphate ester flame retardants (OPFRs) have emerged as preferred alternatives to brominated flame retardants (BFRs) in materials such as building supplies, textiles, and furnishings. Simultaneously, a notable surge in bladder cancer incidences has been observed globally, par...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586792/ https://www.ncbi.nlm.nih.gov/pubmed/37869074 http://dx.doi.org/10.3389/fonc.2023.1260114 |
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author | Zhang, Xiaolei Huang, Wen Huang, Tao Zhang, Jiayi Xu, Aiming Cheng, Yidong Qin, Chao Lu, Qiang Wang, Zengjun |
author_facet | Zhang, Xiaolei Huang, Wen Huang, Tao Zhang, Jiayi Xu, Aiming Cheng, Yidong Qin, Chao Lu, Qiang Wang, Zengjun |
author_sort | Zhang, Xiaolei |
collection | PubMed |
description | In recent years, organophosphate ester flame retardants (OPFRs) have emerged as preferred alternatives to brominated flame retardants (BFRs) in materials such as building supplies, textiles, and furnishings. Simultaneously, a notable surge in bladder cancer incidences has been observed globally, particularly in developed nations, placing it as the 10th most prevalent cancer type. Among the extensive OPFRs, the linkage between triphenyl phosphate (TPP) and bladder cancer remains inadequately investigated. Hence, our study endeavors to elucidate this potential association. We sourced transcriptome profiles and TPP-related data from The Cancer Genome Atlas and Comparative Toxicogenomics databases. Using the ssGSEA algorithm, we established TPP-correlated scores within the bladder cancer cohort. Differentially expressed analysis enabled us to identify key genes in bladder cancer patients. We utilized the LASSO regression analysis, along with univariate and multivariate COX regression analyses to construct a prognostic prediction model. To uncover critical pathways involving key genes, we employed GSEA and GSVA enrichment analyses. Molecular docking analysis was performed to determine the binding capability between TPP and proteins. Our findings reveal that the TPP-centric risk model offers valuable prediction for bladder cancer cohorts. Furthermore, the reliability of this TPP-influenced risk model was verified through ROC curve analysis and survival studies. Intriguingly, TPP exposure appears to bolster the proliferation and invasiveness of bladder cancer cells. This study furnishes new insights into the possible benefits of minimizing TPP exposure for hindering bladder cancer progression. |
format | Online Article Text |
id | pubmed-10586792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105867922023-10-20 Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort Zhang, Xiaolei Huang, Wen Huang, Tao Zhang, Jiayi Xu, Aiming Cheng, Yidong Qin, Chao Lu, Qiang Wang, Zengjun Front Oncol Oncology In recent years, organophosphate ester flame retardants (OPFRs) have emerged as preferred alternatives to brominated flame retardants (BFRs) in materials such as building supplies, textiles, and furnishings. Simultaneously, a notable surge in bladder cancer incidences has been observed globally, particularly in developed nations, placing it as the 10th most prevalent cancer type. Among the extensive OPFRs, the linkage between triphenyl phosphate (TPP) and bladder cancer remains inadequately investigated. Hence, our study endeavors to elucidate this potential association. We sourced transcriptome profiles and TPP-related data from The Cancer Genome Atlas and Comparative Toxicogenomics databases. Using the ssGSEA algorithm, we established TPP-correlated scores within the bladder cancer cohort. Differentially expressed analysis enabled us to identify key genes in bladder cancer patients. We utilized the LASSO regression analysis, along with univariate and multivariate COX regression analyses to construct a prognostic prediction model. To uncover critical pathways involving key genes, we employed GSEA and GSVA enrichment analyses. Molecular docking analysis was performed to determine the binding capability between TPP and proteins. Our findings reveal that the TPP-centric risk model offers valuable prediction for bladder cancer cohorts. Furthermore, the reliability of this TPP-influenced risk model was verified through ROC curve analysis and survival studies. Intriguingly, TPP exposure appears to bolster the proliferation and invasiveness of bladder cancer cells. This study furnishes new insights into the possible benefits of minimizing TPP exposure for hindering bladder cancer progression. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10586792/ /pubmed/37869074 http://dx.doi.org/10.3389/fonc.2023.1260114 Text en Copyright © 2023 Zhang, Huang, Huang, Zhang, Xu, Cheng, Qin, Lu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhang, Xiaolei Huang, Wen Huang, Tao Zhang, Jiayi Xu, Aiming Cheng, Yidong Qin, Chao Lu, Qiang Wang, Zengjun Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort |
title | Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort |
title_full | Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort |
title_fullStr | Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort |
title_full_unstemmed | Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort |
title_short | Integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort |
title_sort | integrative analysis of triphenyl phosphate: contextual interpretation of bladder cancer cohort |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586792/ https://www.ncbi.nlm.nih.gov/pubmed/37869074 http://dx.doi.org/10.3389/fonc.2023.1260114 |
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