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Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia

INTRODUCTION. Medical device colonization by pathogenic microorganisms is a risk factor for increasing infections associated with health care and, consequently, the morbidity and mortality of intubated patients. In Colombia, fungal colonization of endotracheal tubes has not been described, and this...

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Autores principales: Huertas, Mónica Gabriela, Rodríguez, Miguel, Castro, Patricia, Cruz, Sergio Danilo, Cifuentes, Érika Alejandra, Yepes, Andrés Felipe, Zambrano, María Mercedes, Baldión, Ana Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Nacional de Salud 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586799/
https://www.ncbi.nlm.nih.gov/pubmed/37721909
http://dx.doi.org/10.7705/biomedica.6884
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author Huertas, Mónica Gabriela
Rodríguez, Miguel
Castro, Patricia
Cruz, Sergio Danilo
Cifuentes, Érika Alejandra
Yepes, Andrés Felipe
Zambrano, María Mercedes
Baldión, Ana Margarita
author_facet Huertas, Mónica Gabriela
Rodríguez, Miguel
Castro, Patricia
Cruz, Sergio Danilo
Cifuentes, Érika Alejandra
Yepes, Andrés Felipe
Zambrano, María Mercedes
Baldión, Ana Margarita
author_sort Huertas, Mónica Gabriela
collection PubMed
description INTRODUCTION. Medical device colonization by pathogenic microorganisms is a risk factor for increasing infections associated with health care and, consequently, the morbidity and mortality of intubated patients. In Colombia, fungal colonization of endotracheal tubes has not been described, and this information could lead to new therapeutic options for the benefit of patients. OBJECTIVE. To describe the colonizing fungi of the endotracheal tubes from patients in the intensive care unit, along with its antifungal sensitivity profile. MATERIALS AND METHODS. We conducted a descriptive, observational study in two health centers for 12 months. Endotracheal tubes were collected from patients in intensive care units. Samples were processed for culture, fungi identification, and antifungal sensitivity profile assessment. RESULTS. A total of 121 endotracheal tubes, obtained from 113 patients, were analyzed: 41.32 % of the tubes were colonized by Candida albicans (64.62%), C. non-albicans (30.77%), Cryptococcus spp. (3.08%) or molds (1.54%). All fungi evaluated showed a high sensitivity to antifungals, with a mean of 91%. CONCLUSION. Fungal colonization was found in the endotracheal tubes of patients under invasive mechanical ventilation. The antifungal sensitivity profile in these patients was favorable. A clinical study is required to find possible correlations between the colonizing microorganisms and infectivity.
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spelling pubmed-105867992023-10-20 Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia Huertas, Mónica Gabriela Rodríguez, Miguel Castro, Patricia Cruz, Sergio Danilo Cifuentes, Érika Alejandra Yepes, Andrés Felipe Zambrano, María Mercedes Baldión, Ana Margarita Biomedica Artículo Original INTRODUCTION. Medical device colonization by pathogenic microorganisms is a risk factor for increasing infections associated with health care and, consequently, the morbidity and mortality of intubated patients. In Colombia, fungal colonization of endotracheal tubes has not been described, and this information could lead to new therapeutic options for the benefit of patients. OBJECTIVE. To describe the colonizing fungi of the endotracheal tubes from patients in the intensive care unit, along with its antifungal sensitivity profile. MATERIALS AND METHODS. We conducted a descriptive, observational study in two health centers for 12 months. Endotracheal tubes were collected from patients in intensive care units. Samples were processed for culture, fungi identification, and antifungal sensitivity profile assessment. RESULTS. A total of 121 endotracheal tubes, obtained from 113 patients, were analyzed: 41.32 % of the tubes were colonized by Candida albicans (64.62%), C. non-albicans (30.77%), Cryptococcus spp. (3.08%) or molds (1.54%). All fungi evaluated showed a high sensitivity to antifungals, with a mean of 91%. CONCLUSION. Fungal colonization was found in the endotracheal tubes of patients under invasive mechanical ventilation. The antifungal sensitivity profile in these patients was favorable. A clinical study is required to find possible correlations between the colonizing microorganisms and infectivity. Instituto Nacional de Salud 2023-08-31 /pmc/articles/PMC10586799/ /pubmed/37721909 http://dx.doi.org/10.7705/biomedica.6884 Text en https://creativecommons.org/licenses/by/4.0/Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons
spellingShingle Artículo Original
Huertas, Mónica Gabriela
Rodríguez, Miguel
Castro, Patricia
Cruz, Sergio Danilo
Cifuentes, Érika Alejandra
Yepes, Andrés Felipe
Zambrano, María Mercedes
Baldión, Ana Margarita
Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia
title Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia
title_full Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia
title_fullStr Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia
title_full_unstemmed Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia
title_short Descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en Bogotá, Colombia
title_sort descripción de la micobiota de los tubos endotraqueales de pacientes de unidades de cuidados intensivos en bogotá, colombia
topic Artículo Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586799/
https://www.ncbi.nlm.nih.gov/pubmed/37721909
http://dx.doi.org/10.7705/biomedica.6884
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