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Derivation and Validation of a New Equation for Estimating Free Valproate Concentration in Critically Ill Adult Patients

IMPORTANCE: Protein binding of valproate varies among ICU patients, altering the biologically active free valproate concentration (VPAC). Free VPAC is measured at few laboratories and is often discordant with total VPAC. Existing equations to predict free VPAC are either not validated or are inaccur...

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Detalles Bibliográficos
Autores principales:	Liu, Ji Tong, Brown, Caitlin S., Mara, Kristin C., Riker, Richard R., Rabinstein, Alejandro A., Fraser, Gilles L., May, Teresa L., Armstrong, Kaitlin J., Seder, David B., Gagnon, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Observational Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586844/ https://www.ncbi.nlm.nih.gov/pubmed/37868026 http://dx.doi.org/10.1097/CCE.0000000000000987

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