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Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review

Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its potential therapeutic applications. This thorough analysis explores the increasing significance of CBD in treating neurological conditions including epilepsy, multiple sclerosis, Parkinson's disease, and Al...

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Autores principales: Singh, Kuldeep, Bhushan, Bharat, Chanchal, Dilip Kumar, Sharma, Satish Kumar, Rani, Ketki, Yadav, Manoj Kumar, Porwal, Prateek, Kumar, Shivendra, Sharma, Ashwani, Virmani, Tarun, Kumar, Girish, Noman, Abdullah Al
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586905/
https://www.ncbi.nlm.nih.gov/pubmed/37868743
http://dx.doi.org/10.1155/2023/8825358
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author Singh, Kuldeep
Bhushan, Bharat
Chanchal, Dilip Kumar
Sharma, Satish Kumar
Rani, Ketki
Yadav, Manoj Kumar
Porwal, Prateek
Kumar, Shivendra
Sharma, Ashwani
Virmani, Tarun
Kumar, Girish
Noman, Abdullah Al
author_facet Singh, Kuldeep
Bhushan, Bharat
Chanchal, Dilip Kumar
Sharma, Satish Kumar
Rani, Ketki
Yadav, Manoj Kumar
Porwal, Prateek
Kumar, Shivendra
Sharma, Ashwani
Virmani, Tarun
Kumar, Girish
Noman, Abdullah Al
author_sort Singh, Kuldeep
collection PubMed
description Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its potential therapeutic applications. This thorough analysis explores the increasing significance of CBD in treating neurological conditions including epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease, which present major healthcare concerns on a worldwide scale. Despite the lack of available therapies, CBD has been shown to possess a variety of pharmacological effects in preclinical and clinical studies, making it an intriguing competitor. This review brings together the most recent findings on the endocannabinoid and neurotransmitter systems, as well as anti-inflammatory pathways, that underlie CBD's modes of action. Synthesized efficacy and safety assessments for a range of neurological illnesses are included, covering human trials, in vitro studies, and animal models. The investigation includes how CBD could protect neurons, control neuroinflammation, fend off oxidative stress, and manage neuronal excitability. This study emphasizes existing clinical studies and future possibilities in CBD research, addressing research issues such as regulatory complications and contradicting results, and advocates for further investigation of therapeutic efficacy and ideal dose methodologies. By emphasizing CBD's potential to improve patient well-being, this investigation presents a revised viewpoint on its suitability as a therapeutic intervention for neurological illnesses.
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spelling pubmed-105869052023-10-20 Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review Singh, Kuldeep Bhushan, Bharat Chanchal, Dilip Kumar Sharma, Satish Kumar Rani, Ketki Yadav, Manoj Kumar Porwal, Prateek Kumar, Shivendra Sharma, Ashwani Virmani, Tarun Kumar, Girish Noman, Abdullah Al Behav Neurol Review Article Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its potential therapeutic applications. This thorough analysis explores the increasing significance of CBD in treating neurological conditions including epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease, which present major healthcare concerns on a worldwide scale. Despite the lack of available therapies, CBD has been shown to possess a variety of pharmacological effects in preclinical and clinical studies, making it an intriguing competitor. This review brings together the most recent findings on the endocannabinoid and neurotransmitter systems, as well as anti-inflammatory pathways, that underlie CBD's modes of action. Synthesized efficacy and safety assessments for a range of neurological illnesses are included, covering human trials, in vitro studies, and animal models. The investigation includes how CBD could protect neurons, control neuroinflammation, fend off oxidative stress, and manage neuronal excitability. This study emphasizes existing clinical studies and future possibilities in CBD research, addressing research issues such as regulatory complications and contradicting results, and advocates for further investigation of therapeutic efficacy and ideal dose methodologies. By emphasizing CBD's potential to improve patient well-being, this investigation presents a revised viewpoint on its suitability as a therapeutic intervention for neurological illnesses. Hindawi 2023-10-12 /pmc/articles/PMC10586905/ /pubmed/37868743 http://dx.doi.org/10.1155/2023/8825358 Text en Copyright © 2023 Kuldeep Singh et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Singh, Kuldeep
Bhushan, Bharat
Chanchal, Dilip Kumar
Sharma, Satish Kumar
Rani, Ketki
Yadav, Manoj Kumar
Porwal, Prateek
Kumar, Shivendra
Sharma, Ashwani
Virmani, Tarun
Kumar, Girish
Noman, Abdullah Al
Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review
title Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review
title_full Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review
title_fullStr Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review
title_full_unstemmed Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review
title_short Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review
title_sort emerging therapeutic potential of cannabidiol (cbd) in neurological disorders: a comprehensive review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586905/
https://www.ncbi.nlm.nih.gov/pubmed/37868743
http://dx.doi.org/10.1155/2023/8825358
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