The role of extracorporeal life support in extended lung resections for non-small cell lung cancer: a narrative review

BACKGROUND AND OBJECTIVE: Extracorporeal membrane oxygenation (ECMO) may be used as a substitute of traditional cardiopulmonary bypass (CPB) in thoracic surgeries. Extended resections for the treatment of non-small cell lung cancer (NSCLC) occasionally require extracorporeal life support. We present a narrative review of the current clinical uses of extracorporeal devices in this setting of patients. METHODS: We searched Medline database/PubMed for “extra-corporeal membrane oxygenation” and “non-small cell lung carcinoma” in the English language literature between the years 2000 and 2022. KEY CONTENT AND FINDINGS: As opposed to CPB, ECMO is simple, requires minimal or no anticoagulation and elicits fewer complications. T4 lung cancers are frequently considered for surgery in marginally operable patients. ECMO may provide the means to achieve these resections. There are case series of carinal extended resections safely performed under venovenous (VV) or venoarterial (VA) support. The main advantages are a clear surgical field, certainty of proper oxygenation and avoidance of ventilator induced trauma. Left atrial resections have been described with VA ECMO, but the standard of care is still CPB. Descending thoracic aorta resections can also benefit from extracorporeal support, making sure that abdominal organs and lower limbs are well perfused, the heart is not overloaded, and cross clamping is safe. CONCLUSIONS: Surgeons performing extended lung cancer resections should be familiar with ECMO and are encouraged to report their experience.