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Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer

Myeloid-derived suppressor cells (MDSCs), major components maintaining the immune suppressive microenvironment in lung cancer, are relevant to the invasion, metastasis, and poor prognosis of lung cancer, through the regulation of epithelial-mesenchymal transition, remodeling of the immune microenvir...

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Autores principales: He, Zhong-Ning, Zhang, Chun-Yu, Zhao, Yu-Wei, He, Shu-Lin, Li, Yue, Shi, Bo-Lun, Hu, Jia-Qi, Qi, Run-Zhi, Hua, Bao-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587041/
https://www.ncbi.nlm.nih.gov/pubmed/37857728
http://dx.doi.org/10.1007/s12672-023-00793-1
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author He, Zhong-Ning
Zhang, Chun-Yu
Zhao, Yu-Wei
He, Shu-Lin
Li, Yue
Shi, Bo-Lun
Hu, Jia-Qi
Qi, Run-Zhi
Hua, Bao-Jin
author_facet He, Zhong-Ning
Zhang, Chun-Yu
Zhao, Yu-Wei
He, Shu-Lin
Li, Yue
Shi, Bo-Lun
Hu, Jia-Qi
Qi, Run-Zhi
Hua, Bao-Jin
author_sort He, Zhong-Ning
collection PubMed
description Myeloid-derived suppressor cells (MDSCs), major components maintaining the immune suppressive microenvironment in lung cancer, are relevant to the invasion, metastasis, and poor prognosis of lung cancer, through the regulation of epithelial-mesenchymal transition, remodeling of the immune microenvironment, and regulation of angiogenesis. MDSCs regulate T-cell immune functions by maintaining a strong immunosuppressive microenvironment and promoting tumor invasion. This raises the question of whether reversing the immunosuppressive effect of MDSCs on T cells can improve lung cancer treatment. To understand this further, this review explores the interactions and specific mechanisms of different MDSCs subsets, including regulatory T cells, T helper cells, CD8 + T cells, natural killer T cells, and exhausted T cells, as part of the lung cancer immune microenvironment. Second, it focuses on the guiding significance confirmed via clinical liquid biopsy and tissue biopsy that different MDSC subsets improve the prognosis of lung cancer. Finally, we conclude that targeting MDSCs through action targets or signaling pathways can help regulate T-cell immune functions and suppress T-cell exhaustion. In addition, immune checkpoint inhibitors targeting MDSCs may serve as a new approach for enhancing the efficiency of immunotherapy and targeted therapy for lung cancer in the future, providing better comprehensive options for lung cancer treatment.
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spelling pubmed-105870412023-10-21 Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer He, Zhong-Ning Zhang, Chun-Yu Zhao, Yu-Wei He, Shu-Lin Li, Yue Shi, Bo-Lun Hu, Jia-Qi Qi, Run-Zhi Hua, Bao-Jin Discov Oncol Review Myeloid-derived suppressor cells (MDSCs), major components maintaining the immune suppressive microenvironment in lung cancer, are relevant to the invasion, metastasis, and poor prognosis of lung cancer, through the regulation of epithelial-mesenchymal transition, remodeling of the immune microenvironment, and regulation of angiogenesis. MDSCs regulate T-cell immune functions by maintaining a strong immunosuppressive microenvironment and promoting tumor invasion. This raises the question of whether reversing the immunosuppressive effect of MDSCs on T cells can improve lung cancer treatment. To understand this further, this review explores the interactions and specific mechanisms of different MDSCs subsets, including regulatory T cells, T helper cells, CD8 + T cells, natural killer T cells, and exhausted T cells, as part of the lung cancer immune microenvironment. Second, it focuses on the guiding significance confirmed via clinical liquid biopsy and tissue biopsy that different MDSC subsets improve the prognosis of lung cancer. Finally, we conclude that targeting MDSCs through action targets or signaling pathways can help regulate T-cell immune functions and suppress T-cell exhaustion. In addition, immune checkpoint inhibitors targeting MDSCs may serve as a new approach for enhancing the efficiency of immunotherapy and targeted therapy for lung cancer in the future, providing better comprehensive options for lung cancer treatment. Springer US 2023-10-19 /pmc/articles/PMC10587041/ /pubmed/37857728 http://dx.doi.org/10.1007/s12672-023-00793-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
He, Zhong-Ning
Zhang, Chun-Yu
Zhao, Yu-Wei
He, Shu-Lin
Li, Yue
Shi, Bo-Lun
Hu, Jia-Qi
Qi, Run-Zhi
Hua, Bao-Jin
Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
title Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
title_full Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
title_fullStr Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
title_full_unstemmed Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
title_short Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
title_sort regulation of t cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587041/
https://www.ncbi.nlm.nih.gov/pubmed/37857728
http://dx.doi.org/10.1007/s12672-023-00793-1
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