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Developing mitochondrial base editors with diverse context compatibility and high fidelity via saturated spacer library

DddA-derived cytosine base editors (DdCBEs) greatly facilitated the basic and therapeutic research of mitochondrial DNA mutation diseases. Here we devise a saturated spacer library and successfully identify seven DddA homologs by performing high-throughput sequencing based screen. DddAs of Streptomy...

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Detalles Bibliográficos
Autores principales:	Sun, Haifeng, Wang, Zhaojun, Shen, Limini, Feng, Yeling, Han, Lu, Qian, Xuezhen, Meng, Runde, Ji, Kangming, Liang, Dong, Zhou, Fei, Lou, Xin, Zhang, Jun, Shen, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587121/ https://www.ncbi.nlm.nih.gov/pubmed/37857619 http://dx.doi.org/10.1038/s41467-023-42359-3

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