Cargando…

Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft

PURPOSE: Although the popularity of Descemet membrane endothelial keratoplasty (DMEK) is increased, there is still few clinical studies in Korea. In this study, we aimed to report the initial clinical outcomes of DMEK in patients followed up for more than 6 months. METHODS: A total of 96 eyes that u...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Minha, Kim, Kang Hyun, Lee, Hyung Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Ophthalmological Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587462/
https://www.ncbi.nlm.nih.gov/pubmed/37562438
http://dx.doi.org/10.3341/kjo.2023.0053
_version_ 1785123368960262144
author Kim, Minha
Kim, Kang Hyun
Lee, Hyung Keun
author_facet Kim, Minha
Kim, Kang Hyun
Lee, Hyung Keun
author_sort Kim, Minha
collection PubMed
description PURPOSE: Although the popularity of Descemet membrane endothelial keratoplasty (DMEK) is increased, there is still few clinical studies in Korea. In this study, we aimed to report the initial clinical outcomes of DMEK in patients followed up for more than 6 months. METHODS: A total of 96 eyes that underwent DMEK by a single surgeon for Fuchs endothelial corneal dystrophy, pseudophakic bullous keratopathy, or other indications were evaluated for best-corrected visual acuity (BCVA), endothelial cell density (ECD), central corneal thickness (CCT), postoperative complications, and graft survival. RESULTS: The postoperative BCVA significantly increased compared to the preoperative BCVA by 59.4% (1.00 ± 0.77 logarithm of the minimum angle of resolution vs. 0.67 ± 0.76 logarithm of the minimum angle of resolution, p < 0.001). The average preoperative ECD was 754 ± 382 cells/mm(2), increasing to 1,333 ± 562 cells/mm(2) at 3 months (76.8%, p < 0.001), 1,334 ± 632 cells/mm(2) at 6 months (76.9%, p < 0.001), 1,121 ± 474 cells/mm(2) at 12 months (48.7%, p = 0.024), and 972 ± 458 cells/mm(2) at 24 months postoperatively (28.9%, p = 0.445). Compared to 3 months, the ECD declined by 15.9% at 12 months (p = 0.009) and 27.1% at 24 months postoperatively (p = 0.158). The average CCT was 675 ± 113 μm preoperatively, decreasing to 581 ± 102, 574 ± 101, and 594 ± 94 μm at 6, 12, and 24 months after DMEK, respectively (p < 0.001 between all follow-up time points). Allograft rejection was detected in three (3.1%) and 14 eyes (14.6%) underwent retransplantation at an average of 10.1 ± 8.4 months after DMEK. CONCLUSIONS: DMEK is promising for maintaining corneal clarity, low postoperative complication rates, and stable graft longevity.
format Online
Article
Text
id pubmed-10587462
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Korean Ophthalmological Society
record_format MEDLINE/PubMed
spelling pubmed-105874622023-10-21 Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft Kim, Minha Kim, Kang Hyun Lee, Hyung Keun Korean J Ophthalmol Original Article PURPOSE: Although the popularity of Descemet membrane endothelial keratoplasty (DMEK) is increased, there is still few clinical studies in Korea. In this study, we aimed to report the initial clinical outcomes of DMEK in patients followed up for more than 6 months. METHODS: A total of 96 eyes that underwent DMEK by a single surgeon for Fuchs endothelial corneal dystrophy, pseudophakic bullous keratopathy, or other indications were evaluated for best-corrected visual acuity (BCVA), endothelial cell density (ECD), central corneal thickness (CCT), postoperative complications, and graft survival. RESULTS: The postoperative BCVA significantly increased compared to the preoperative BCVA by 59.4% (1.00 ± 0.77 logarithm of the minimum angle of resolution vs. 0.67 ± 0.76 logarithm of the minimum angle of resolution, p < 0.001). The average preoperative ECD was 754 ± 382 cells/mm(2), increasing to 1,333 ± 562 cells/mm(2) at 3 months (76.8%, p < 0.001), 1,334 ± 632 cells/mm(2) at 6 months (76.9%, p < 0.001), 1,121 ± 474 cells/mm(2) at 12 months (48.7%, p = 0.024), and 972 ± 458 cells/mm(2) at 24 months postoperatively (28.9%, p = 0.445). Compared to 3 months, the ECD declined by 15.9% at 12 months (p = 0.009) and 27.1% at 24 months postoperatively (p = 0.158). The average CCT was 675 ± 113 μm preoperatively, decreasing to 581 ± 102, 574 ± 101, and 594 ± 94 μm at 6, 12, and 24 months after DMEK, respectively (p < 0.001 between all follow-up time points). Allograft rejection was detected in three (3.1%) and 14 eyes (14.6%) underwent retransplantation at an average of 10.1 ± 8.4 months after DMEK. CONCLUSIONS: DMEK is promising for maintaining corneal clarity, low postoperative complication rates, and stable graft longevity. Korean Ophthalmological Society 2023-10 2023-08-10 /pmc/articles/PMC10587462/ /pubmed/37562438 http://dx.doi.org/10.3341/kjo.2023.0053 Text en © 2023 The Korean Ophthalmological Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access journal distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Minha
Kim, Kang Hyun
Lee, Hyung Keun
Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft
title Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft
title_full Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft
title_fullStr Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft
title_full_unstemmed Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft
title_short Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft
title_sort clinical outcomes of descemet membrane endothelial keratoplasty using a preloaded imported graft
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587462/
https://www.ncbi.nlm.nih.gov/pubmed/37562438
http://dx.doi.org/10.3341/kjo.2023.0053
work_keys_str_mv AT kimminha clinicaloutcomesofdescemetmembraneendothelialkeratoplastyusingapreloadedimportedgraft
AT kimkanghyun clinicaloutcomesofdescemetmembraneendothelialkeratoplastyusingapreloadedimportedgraft
AT leehyungkeun clinicaloutcomesofdescemetmembraneendothelialkeratoplastyusingapreloadedimportedgraft