Targeting 2-Oxoglutarate–Dependent Dioxygenases Promotes Metabolic Reprogramming That Protects against Lethal SARS-CoV-2 Infection in the K18-hACE2 Transgenic Mouse Model

Dysregulation of host metabolism is a feature of lethal SARS-CoV-2 infection. Perturbations in α-ketoglutarate levels can elicit metabolic reprogramming through 2-oxoglutarate–dependent dioxygenases (2-ODDGs), leading to stabilization of the transcription factor HIF-1α. HIF1-α activation has been re...

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Detalles Bibliográficos
Autores principales: Jessop, Forrest, Schwarz, Benjamin, Bohrnsen, Eric, Miltko, Molly, Shaia, Carl, Bosio, Catharine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587500/
https://www.ncbi.nlm.nih.gov/pubmed/37417946
http://dx.doi.org/10.4049/immunohorizons.2300048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587500/
https://www.ncbi.nlm.nih.gov/pubmed/37417946
http://dx.doi.org/10.4049/immunohorizons.2300048

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