The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa

LEAP-2 is a ghrelin antagonist with an anorexigenic drive. This study investigates the evolution of plasma ghrelin and LEAP-2 concentrations in 29 patients with anorexia nervosa (AN) before and after refeeding and compares it to physiological adaptations during fasting in healthy controls or to mous...

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Autores principales: Tezenas du Montcel, Chloé, Duriez, Philibert, Cao, Jingxian, Lebrun, Nicolas, Ramoz, Nicolas, Viltart, Odile, Gorwood, Philip, Tolle, Virginie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587521/
https://www.ncbi.nlm.nih.gov/pubmed/37867951
http://dx.doi.org/10.1016/j.isci.2023.107996
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author Tezenas du Montcel, Chloé
Duriez, Philibert
Cao, Jingxian
Lebrun, Nicolas
Ramoz, Nicolas
Viltart, Odile
Gorwood, Philip
Tolle, Virginie
author_facet Tezenas du Montcel, Chloé
Duriez, Philibert
Cao, Jingxian
Lebrun, Nicolas
Ramoz, Nicolas
Viltart, Odile
Gorwood, Philip
Tolle, Virginie
author_sort Tezenas du Montcel, Chloé
collection PubMed
description LEAP-2 is a ghrelin antagonist with an anorexigenic drive. This study investigates the evolution of plasma ghrelin and LEAP-2 concentrations in 29 patients with anorexia nervosa (AN) before and after refeeding and compares it to physiological adaptations during fasting in healthy controls or to mouse model of chronic food restriction and refeeding. Acute and chronic food restriction decrease LEAP-2 and increase ghrelin concentrations in both humans and mice, while patients with AN displayed higher ghrelin and LEAP-2 concentrations before than after refeeding (p = 0.043). After 6 months follow-up, patients with unstable weight gain (n = 17) had significantly decreased LEAP-2 concentrations after refeeding (p = 0.044), in contrast to patients with stable weight gain (n = 12). We provide evidence that the ghrelin/LEAP-2 system is not regulated according to the nutritional status in AN, in contrast to what is physiologically expected when coping with food restriction.
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spelling pubmed-105875212023-10-21 The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa Tezenas du Montcel, Chloé Duriez, Philibert Cao, Jingxian Lebrun, Nicolas Ramoz, Nicolas Viltart, Odile Gorwood, Philip Tolle, Virginie iScience Article LEAP-2 is a ghrelin antagonist with an anorexigenic drive. This study investigates the evolution of plasma ghrelin and LEAP-2 concentrations in 29 patients with anorexia nervosa (AN) before and after refeeding and compares it to physiological adaptations during fasting in healthy controls or to mouse model of chronic food restriction and refeeding. Acute and chronic food restriction decrease LEAP-2 and increase ghrelin concentrations in both humans and mice, while patients with AN displayed higher ghrelin and LEAP-2 concentrations before than after refeeding (p = 0.043). After 6 months follow-up, patients with unstable weight gain (n = 17) had significantly decreased LEAP-2 concentrations after refeeding (p = 0.044), in contrast to patients with stable weight gain (n = 12). We provide evidence that the ghrelin/LEAP-2 system is not regulated according to the nutritional status in AN, in contrast to what is physiologically expected when coping with food restriction. Elsevier 2023-09-22 /pmc/articles/PMC10587521/ /pubmed/37867951 http://dx.doi.org/10.1016/j.isci.2023.107996 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tezenas du Montcel, Chloé
Duriez, Philibert
Cao, Jingxian
Lebrun, Nicolas
Ramoz, Nicolas
Viltart, Odile
Gorwood, Philip
Tolle, Virginie
The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa
title The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa
title_full The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa
title_fullStr The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa
title_full_unstemmed The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa
title_short The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa
title_sort role of dysregulated ghrelin/leap-2 balance in anorexia nervosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587521/
https://www.ncbi.nlm.nih.gov/pubmed/37867951
http://dx.doi.org/10.1016/j.isci.2023.107996
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