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Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor

INTRODUCTION: In this research, our primary objective was to explore the correlation between basal ganglia dopaminergic neurotransmission, assessed using 123I-FP-CIT (DAT-SPECT), and finger movements abnormalities in patients with essential tremor (ET) and Parkinson’s disease (PD). METHODS: We enrol...

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Autores principales: Colella, Donato, Passaretti, Massimiliano, Frantellizzi, Viviana, Silvia De Feo, Maria, Cannavacciuolo, Antonio, Angelini, Luca, Birreci, Daniele, Costa, Davide, Paparella, Giulia, Guerra, Andrea, De Vincentis, Giuseppe, Berardelli, Alfredo, Bologna, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587600/
https://www.ncbi.nlm.nih.gov/pubmed/37847966
http://dx.doi.org/10.1016/j.nicl.2023.103526
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author Colella, Donato
Passaretti, Massimiliano
Frantellizzi, Viviana
Silvia De Feo, Maria
Cannavacciuolo, Antonio
Angelini, Luca
Birreci, Daniele
Costa, Davide
Paparella, Giulia
Guerra, Andrea
De Vincentis, Giuseppe
Berardelli, Alfredo
Bologna, Matteo
author_facet Colella, Donato
Passaretti, Massimiliano
Frantellizzi, Viviana
Silvia De Feo, Maria
Cannavacciuolo, Antonio
Angelini, Luca
Birreci, Daniele
Costa, Davide
Paparella, Giulia
Guerra, Andrea
De Vincentis, Giuseppe
Berardelli, Alfredo
Bologna, Matteo
author_sort Colella, Donato
collection PubMed
description INTRODUCTION: In this research, our primary objective was to explore the correlation between basal ganglia dopaminergic neurotransmission, assessed using 123I-FP-CIT (DAT-SPECT), and finger movements abnormalities in patients with essential tremor (ET) and Parkinson’s disease (PD). METHODS: We enrolled 16 patients with ET, 17 with PD, and 18 healthy controls (HC). Each participant underwent comprehensive clinical evaluations, kinematic assessments of finger tapping. ET and PD patients underwent DAT-SPECT imaging. The DAT-SPECT scans were subjected to both visual and semi-quantitative analysis using DaTQUANT®. We then investigated the correlations between the clinical, kinematic, and DAT-SPECT data, in patients. RESULTS: Our findings confirm that individuals with ET exhibited slower finger tapping than HC. Visual evaluation of radiotracer uptake in both striata demonstrated normal levels within the ET patient cohort, while PD patients displayed reduced uptake. However, there was notable heterogeneity in the quantification of uptake within the striata among ET patients. Additionally, we found a correlation between the amount of radiotracer uptake in the striatum and movement velocity during finger tapping in patients. Specifically, lower radioligand uptake corresponded to decreased movement velocity (ET: coef. = 0.53, p-adj = 0.03; PD: coef. = 0.59, p-adj = 0.01). CONCLUSION: The study's findings suggest a potential link between subtle changes in central dopaminergic tone and altered voluntary movement execution, in ET. These results provide further insights into the pathophysiology of ET. However, longitudinal studies are essential to determine whether the slight reduction in dopaminergic tone observed in ET patients represents a distinct subtype of the disease or could serve as a predictor for the clinical progression into PD.
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spelling pubmed-105876002023-10-21 Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor Colella, Donato Passaretti, Massimiliano Frantellizzi, Viviana Silvia De Feo, Maria Cannavacciuolo, Antonio Angelini, Luca Birreci, Daniele Costa, Davide Paparella, Giulia Guerra, Andrea De Vincentis, Giuseppe Berardelli, Alfredo Bologna, Matteo Neuroimage Clin Regular Article INTRODUCTION: In this research, our primary objective was to explore the correlation between basal ganglia dopaminergic neurotransmission, assessed using 123I-FP-CIT (DAT-SPECT), and finger movements abnormalities in patients with essential tremor (ET) and Parkinson’s disease (PD). METHODS: We enrolled 16 patients with ET, 17 with PD, and 18 healthy controls (HC). Each participant underwent comprehensive clinical evaluations, kinematic assessments of finger tapping. ET and PD patients underwent DAT-SPECT imaging. The DAT-SPECT scans were subjected to both visual and semi-quantitative analysis using DaTQUANT®. We then investigated the correlations between the clinical, kinematic, and DAT-SPECT data, in patients. RESULTS: Our findings confirm that individuals with ET exhibited slower finger tapping than HC. Visual evaluation of radiotracer uptake in both striata demonstrated normal levels within the ET patient cohort, while PD patients displayed reduced uptake. However, there was notable heterogeneity in the quantification of uptake within the striata among ET patients. Additionally, we found a correlation between the amount of radiotracer uptake in the striatum and movement velocity during finger tapping in patients. Specifically, lower radioligand uptake corresponded to decreased movement velocity (ET: coef. = 0.53, p-adj = 0.03; PD: coef. = 0.59, p-adj = 0.01). CONCLUSION: The study's findings suggest a potential link between subtle changes in central dopaminergic tone and altered voluntary movement execution, in ET. These results provide further insights into the pathophysiology of ET. However, longitudinal studies are essential to determine whether the slight reduction in dopaminergic tone observed in ET patients represents a distinct subtype of the disease or could serve as a predictor for the clinical progression into PD. Elsevier 2023-10-10 /pmc/articles/PMC10587600/ /pubmed/37847966 http://dx.doi.org/10.1016/j.nicl.2023.103526 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Colella, Donato
Passaretti, Massimiliano
Frantellizzi, Viviana
Silvia De Feo, Maria
Cannavacciuolo, Antonio
Angelini, Luca
Birreci, Daniele
Costa, Davide
Paparella, Giulia
Guerra, Andrea
De Vincentis, Giuseppe
Berardelli, Alfredo
Bologna, Matteo
Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
title Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
title_full Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
title_fullStr Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
title_full_unstemmed Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
title_short Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
title_sort subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587600/
https://www.ncbi.nlm.nih.gov/pubmed/37847966
http://dx.doi.org/10.1016/j.nicl.2023.103526
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