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Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review
Arthritic disorders have become one of the main contributors to the global burden of disease. Today, they are one of the leading causes of chronic pain and disability worldwide. Current therapies are incapable of treating pain sufficiently and preventing disease progression. The lack of understandin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587608/ https://www.ncbi.nlm.nih.gov/pubmed/37869169 http://dx.doi.org/10.3389/fmed.2023.1255215 |
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author | Ritter, Jana Menger, Maximilian Herath, Steven C. Histing, Tina Kolbenschlag, Jonas Daigeler, Adrien Heinzel, Johannes C. Prahm, Cosima |
author_facet | Ritter, Jana Menger, Maximilian Herath, Steven C. Histing, Tina Kolbenschlag, Jonas Daigeler, Adrien Heinzel, Johannes C. Prahm, Cosima |
author_sort | Ritter, Jana |
collection | PubMed |
description | Arthritic disorders have become one of the main contributors to the global burden of disease. Today, they are one of the leading causes of chronic pain and disability worldwide. Current therapies are incapable of treating pain sufficiently and preventing disease progression. The lack of understanding basic mechanisms underlying the initiation, maintenance and progression of arthritic disorders and related symptoms represent the major obstacle in the search for adequate treatments. For a long time, histological evaluation of joint pathology was the predominant outcome parameter in preclinical arthritis models. Nevertheless, quantification of pain and functional limitations analogs to arthritis related symptoms in humans is essential to enable bench to bedside translation and to evaluate the effectiveness of new treatment strategies. As the experience of pain and functional deficits are often associated with altered gait behavior, in the last decades, automated gait analysis has become a well-established tool for the quantitative evaluation of the sequalae of arthritic disorders in animal models. The purpose of this review is to provide a detailed overview on the current literature on the use of the CatWalk gait analysis system in rodent models of arthritic disorders, e.g., Osteoarthritis, Monoarthritis and Rheumatoid Arthritis. Special focus is put on the assessment and monitoring of pain-related behavior during the course of the disease. The capability of evaluating the effect of distinct treatment strategies and the future potential for the application of the CatWalk in rodent models of arthritic disorders is also addressed in this review. Finally, we discuss important consideration and provide recommendations on the use of the CatWalk in preclinical models of arthritic diseases. |
format | Online Article Text |
id | pubmed-10587608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105876082023-10-21 Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review Ritter, Jana Menger, Maximilian Herath, Steven C. Histing, Tina Kolbenschlag, Jonas Daigeler, Adrien Heinzel, Johannes C. Prahm, Cosima Front Med (Lausanne) Medicine Arthritic disorders have become one of the main contributors to the global burden of disease. Today, they are one of the leading causes of chronic pain and disability worldwide. Current therapies are incapable of treating pain sufficiently and preventing disease progression. The lack of understanding basic mechanisms underlying the initiation, maintenance and progression of arthritic disorders and related symptoms represent the major obstacle in the search for adequate treatments. For a long time, histological evaluation of joint pathology was the predominant outcome parameter in preclinical arthritis models. Nevertheless, quantification of pain and functional limitations analogs to arthritis related symptoms in humans is essential to enable bench to bedside translation and to evaluate the effectiveness of new treatment strategies. As the experience of pain and functional deficits are often associated with altered gait behavior, in the last decades, automated gait analysis has become a well-established tool for the quantitative evaluation of the sequalae of arthritic disorders in animal models. The purpose of this review is to provide a detailed overview on the current literature on the use of the CatWalk gait analysis system in rodent models of arthritic disorders, e.g., Osteoarthritis, Monoarthritis and Rheumatoid Arthritis. Special focus is put on the assessment and monitoring of pain-related behavior during the course of the disease. The capability of evaluating the effect of distinct treatment strategies and the future potential for the application of the CatWalk in rodent models of arthritic disorders is also addressed in this review. Finally, we discuss important consideration and provide recommendations on the use of the CatWalk in preclinical models of arthritic diseases. Frontiers Media S.A. 2023-10-06 /pmc/articles/PMC10587608/ /pubmed/37869169 http://dx.doi.org/10.3389/fmed.2023.1255215 Text en Copyright © 2023 Ritter, Menger, Herath, Histing, Kolbenschlag, Daigeler, Heinzel and Prahm. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Ritter, Jana Menger, Maximilian Herath, Steven C. Histing, Tina Kolbenschlag, Jonas Daigeler, Adrien Heinzel, Johannes C. Prahm, Cosima Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review |
title | Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review |
title_full | Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review |
title_fullStr | Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review |
title_full_unstemmed | Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review |
title_short | Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device – a narrative review |
title_sort | translational evaluation of gait behavior in rodent models of arthritic disorders with the catwalk device – a narrative review |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587608/ https://www.ncbi.nlm.nih.gov/pubmed/37869169 http://dx.doi.org/10.3389/fmed.2023.1255215 |
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