Modeling the protein binding non-linearity in population pharmacokinetic model of valproic acid in children with epilepsy: a systematic evaluation study

Background: Several studies have investigated the population pharmacokinetics (popPK) of valproic acid (VPA) in children with epilepsy. However, the predictive performance of these models in the extrapolation to other clinical environments has not been studied. Hence, this study evaluated the predic...

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Detalles Bibliográficos
Autores principales: Zhang, Lina, Liu, Maochang, Qin, Weiwei, Shi, Dandan, Mao, Junjun, Li, Zeyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587682/
https://www.ncbi.nlm.nih.gov/pubmed/37869748
http://dx.doi.org/10.3389/fphar.2023.1228641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587682/
https://www.ncbi.nlm.nih.gov/pubmed/37869748
http://dx.doi.org/10.3389/fphar.2023.1228641

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