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Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively

BACKGROUND: Infection-associated acute encephalopathy (AE) is a clinical condition caused by a variety of pathogens, particularly common viruses. In some cases, this condition could be characterized by a sudden onset and a rapid progression, leading to severe neurological sequelae, including acute e...

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Autores principales: Ni, Jingwen, Fang, Boliang, Xu, Huan, Liu, Yahui, Fang, Kenan, Li, Shujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587721/
https://www.ncbi.nlm.nih.gov/pubmed/37867568
http://dx.doi.org/10.1016/j.idcr.2023.e01910
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author Ni, Jingwen
Fang, Boliang
Xu, Huan
Liu, Yahui
Fang, Kenan
Li, Shujun
author_facet Ni, Jingwen
Fang, Boliang
Xu, Huan
Liu, Yahui
Fang, Kenan
Li, Shujun
author_sort Ni, Jingwen
collection PubMed
description BACKGROUND: Infection-associated acute encephalopathy (AE) is a clinical condition caused by a variety of pathogens, particularly common viruses. In some cases, this condition could be characterized by a sudden onset and a rapid progression, leading to severe neurological sequelae, including acute encephalopathy with biphasic seizures and late reduced diffusion, hemorrhagic shock and encephalopathy syndrome, etc. CASE PRESENTATION: In this study, it was reported that three previously healthy children developed acute encephalopathy/encephalitis symptoms with different neurological sequelae after either Influenza A Virus or Human Herpesvirus 1 infection, presenting with fever and convulsions. What's more, after performing the gene exon detection for these three children, it was found that there are abnormal genes corresponding to their neurological sequelae, including SLC25A19 and TICAM1. CONCLUSIONS: Therefore, comparing to children with common encephalitis, for children with encephalitis whose progression is rapid and clinical manifestations such as recurrent fever and frequent convulsions is difficult to improve, whole-exome sequencing can be a valuable tool for identifying encephalitis-associated genetic variants and providing strong evidence for prognostic prediction.
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spelling pubmed-105877212023-10-21 Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively Ni, Jingwen Fang, Boliang Xu, Huan Liu, Yahui Fang, Kenan Li, Shujun IDCases Case Report BACKGROUND: Infection-associated acute encephalopathy (AE) is a clinical condition caused by a variety of pathogens, particularly common viruses. In some cases, this condition could be characterized by a sudden onset and a rapid progression, leading to severe neurological sequelae, including acute encephalopathy with biphasic seizures and late reduced diffusion, hemorrhagic shock and encephalopathy syndrome, etc. CASE PRESENTATION: In this study, it was reported that three previously healthy children developed acute encephalopathy/encephalitis symptoms with different neurological sequelae after either Influenza A Virus or Human Herpesvirus 1 infection, presenting with fever and convulsions. What's more, after performing the gene exon detection for these three children, it was found that there are abnormal genes corresponding to their neurological sequelae, including SLC25A19 and TICAM1. CONCLUSIONS: Therefore, comparing to children with common encephalitis, for children with encephalitis whose progression is rapid and clinical manifestations such as recurrent fever and frequent convulsions is difficult to improve, whole-exome sequencing can be a valuable tool for identifying encephalitis-associated genetic variants and providing strong evidence for prognostic prediction. Elsevier 2023-10-11 /pmc/articles/PMC10587721/ /pubmed/37867568 http://dx.doi.org/10.1016/j.idcr.2023.e01910 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ni, Jingwen
Fang, Boliang
Xu, Huan
Liu, Yahui
Fang, Kenan
Li, Shujun
Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively
title Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively
title_full Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively
title_fullStr Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively
title_full_unstemmed Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively
title_short Case report: Influenza A virus and Human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the SLC25A19 andTICAM1 gene, respectively
title_sort case report: influenza a virus and human herpesvirus 1 infection-associated acute encephalopathy in children with the mutations in the slc25a19 andticam1 gene, respectively
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587721/
https://www.ncbi.nlm.nih.gov/pubmed/37867568
http://dx.doi.org/10.1016/j.idcr.2023.e01910
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