Cargando…

Pyrrolizine/indolizine-bearing (un)substituted isoindole moiety: design, synthesis, antiproliferative and MDR reversal activities, and in silico studies

Two new series of pyrrolizine/indolizine derivative-bearing (un)substituted isoindole moiety were designed and synthesized. The anticancer potential of the new compounds was evaluated against hepatocellular carcinoma (HepG-2), colorectal carcinoma, colon cancer (HCT-116), and breast cancer (MCF-7) c...

Descripción completa

Detalles Bibliográficos
Autores principales:	AbdelSamad, Amr L., El-Saadi, Mohammed T., Gouda, Ahmed M., AboulMagd, Asmaa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587743/ https://www.ncbi.nlm.nih.gov/pubmed/37869384 http://dx.doi.org/10.1039/d3ra05310e

Ejemplares similares

Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies
por: Abourehab, Mohammed A. S., et al.
Publicado: (2021)

Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents
por: Shawky, Ahmed M., et al.
Publicado: (2021)

Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities
por: Shawky, Ahmed M., et al.
Publicado: (2020)

In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases
por: Almalki, Faisal A., et al.
Publicado: (2021)

N,N′-Di-Boc-2H-Isoindole-2-carboxamidine—First Guanidine-Substituted Isoindole
por: Štrbac, Petar, et al.
Publicado: (2022)

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
por: Mansour, Mostafa A., et al.
Publicado: (2020)

Ligand-based design, molecular dynamics and ADMET studies of suggested SARS-CoV-2 M(pro) inhibitors
por: Mohamed, Nada M., et al.
Publicado: (2021)

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities
por: Almansour, Abdulrahman I., et al.
Publicado: (2014)

Origin of the Diastereoselectivity of the Heterogeneous Hydrogenation of a Substituted Indolizine
por: Cormanich, Rodrigo A., et al.
Publicado: (2020)

Ecological HPLC method for analyzing an antidiabetic drug in real rat plasma samples and studying the effects of concurrently administered fenugreek extract on its pharmacokinetics
por: Abdelwahab, Nada S., et al.
Publicado: (2021)

Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety
por: Li, Fang-Yao, et al.
Publicado: (2019)

An Improved Synthesis of Some 5-Substituted Indolizines Using Regiospecific Lithiation
por: Kuznetsov, Alexey G., et al.
Publicado: (2005)

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors
por: Sardaru, Monica-Cornelia, et al.
Publicado: (2020)

Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors
por: AboulMagd, Asmaa M., et al.
Publicado: (2020)

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression
por: Ahmed, Yasmin M., et al.
Publicado: (2022)

Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review
por: Mansour, Mostafa A., et al.
Publicado: (2023)

Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety
por: Zhu, Xia-Ping, et al.
Publicado: (2020)

Sydnone C-4 heteroarylation with an indolizine ring via Chichibabin indolizine synthesis
por: Albota, Florin, et al.
Publicado: (2016)

Garcinia cambogia Phenolics as Potent Anti-COVID-19 Agents: Phytochemical Profiling, Biological Activities, and Molecular Docking
por: Aati, Hanan Y., et al.
Publicado: (2022)

The chemistry of isoindole natural products
por: Speck, Klaus, et al.
Publicado: (2013)

Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agents via carbonic anhydrase IX inhibition
por: Nemr, Mohamed T. M., et al.
Publicado: (2021)

Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1–7 via PI3K/AKT/mTOR Signaling Pathway
por: Ahmed, Yasmin M., et al.
Publicado: (2022)

Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues
por: Venugopala, Katharigatta Narayanaswamy, et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action
por: El-Sheref, Essmat M., et al.
Publicado: (2022)

Antiulcer secondary metabolites from Elaeocarpus grandis, family Elaeocarpaceae, supported by in silico studies
por: Mohie El-Dien, Radwa Taher, et al.
Publicado: (2020)

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
por: Sayed, Ahmed M., et al.
Publicado: (2020)

Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties
por: Litim, Bilal, et al.
Publicado: (2021)

One-pot synthesis of pyrazolo[4,3-d]thiazole derivatives containing α-aminophosphonate as potential Mur A inhibitors against MDR pathogens with radiosterilization and molecular modeling simulation
por: Ragab, Ahmed, et al.
Publicado: (2023)

Three-component assembly of stabilized fluorescent isoindoles
por: Maslivetc, Vladimir A., et al.
Publicado: (2022)

Diethyl indolizine-1,3-dicarboxylate
por: Gu, Wei-Jin, et al.
Publicado: (2010)

Renewable Furfural-Based Polyesters Bearing Sulfur-Bridged Difuran Moieties with High Oxygen Barrier Properties
por: Ahmed, Asmaa M., et al.
Publicado: (2022)

2,3-Dihydro-1H-pyrrolizin-1-one
por: Ali, Yousaf, et al.
Publicado: (2010)

Isothiourea-catalysed enantioselective pyrrolizine synthesis: synthetic and computational studies
por: Stark, Daniel G., et al.
Publicado: (2016)

Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-Inflammatory/Analgesic Activities and Low Ulcerogenic Liability
por: Gouda, Ahmed M., et al.
Publicado: (2016)

Ethyl 3-benzoylindolizine-1-carboxylate
por: Gu, Wei-Jin, et al.
Publicado: (2011)

Pyrazino[2,3-b]indolizine-10-carbonitrile
por: Stefańska, Anita, et al.
Publicado: (2009)

Design, Synthesis, and In Vitro Antiproliferative Activity of Hydantoin and Purine Derivatives with the 4-Acetylphenylpiperazinylalkyl Moiety
por: Zagórska, Agnieszka, et al.
Publicado: (2021)

Novel iodoquinazolinones bearing sulfonamide moiety as potential antioxidants and neuroprotectors
por: Soliman, Aiten M., et al.
Publicado: (2023)

Correction: Triple-negative breast cancer suppressive activities, antioxidants and pharmacophore model of new acylated rhamnopyranoses from Premna odorata
por: Elmaidomy, Abeer H., et al.
Publicado: (2021)

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines
por: Youssef, Magdy M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jk52j50482luup5kt0moqdc819